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    TIMELESS timeless circadian regulator [ Bos taurus (domestic cattle) ]

    Gene ID: 522884, updated on 30-Jan-2025

    Summary

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    Official Symbol
    TIMELESSprovided by VGNC
    Official Full Name
    timeless circadian regulatorprovided by VGNC
    Primary source
    VGNC:VGNC:35869
    See related
    BGD:BT26426; EnsemblRapid:ENSBTAG00070012102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Summary
    The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]
    Orthologs
    human mouse all
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    Genomic context

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    See TIMELESS in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (56939056..56964353)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene glutaminase 2 Neighboring gene SPRY domain containing 4 Neighboring gene major intrinsic protein of lens fiber Neighboring gene apolipoprotein F Neighboring gene apolipoprotein N Neighboring gene signal transducer and activator of transcription 2 Neighboring gene interleukin 23 subunit alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159790

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA replication checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in replication fork arrest IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of replication fork protection complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein timeless homolog
    Names
    timeless circadian clock
    timeless homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102071.2 → NP_001095541.2  protein timeless homolog

      See identical proteins and their annotated locations for NP_001095541.2

      Status: VALIDATED

      Source sequence(s)
      NKLS02000005
      UniProtKB/TrEMBL
      F1MQI4
      Related
      ENSBTAP00070016369.1, ENSBTAT00070027358.1
      Conserved Domains (2) summary
      pfam05029
      Location:722 → 1211
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:21 → 280
      TIMELESS; Timeless protein

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      56939056..56964353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024991788.2 → XP_024847556.1  protein timeless homolog isoform X1

      UniProtKB/TrEMBL
      F1MQI4
      Conserved Domains (2) summary
      pfam05029
      Location:722 → 1211
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:21 → 280
      TIMELESS; Timeless protein

    2. XM_010805186.4 → XP_010803488.1  protein timeless homolog isoform X1

      See identical proteins and their annotated locations for XP_010803488.1

      UniProtKB/TrEMBL
      F1MQI4
      Conserved Domains (2) summary
      pfam05029
      Location:722 → 1211
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:21 → 280
      TIMELESS; Timeless protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_174673.2: Suppressed sequence

      Description
      NM_174673.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version

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