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    OTULIN OTU deubiquitinase with linear linkage specificity [ Bos taurus (domestic cattle) ]

    Gene ID: 508963, updated on 1-Jan-2025

    Summary

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    Official Symbol
    OTULINprovided by VGNC
    Official Full Name
    OTU deubiquitinase with linear linkage specificityprovided by VGNC
    Primary source
    VGNC:VGNC:32501
    See related
    Ensembl:ENSBTAG00000003186
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    FAM105B
    Orthologs
    human mouse all
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    Genomic context

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    See OTULIN in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (58490255..58526786, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene ANKH inorganic pyrophosphate transport regulator Neighboring gene uncharacterized LOC132343251 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene uncharacterized LOC132343250 Neighboring gene OTU deubiquitinase with linear linkage specificity like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein linear deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin thioesterase otulin
    Names
    family with sequence similarity 105, member B
    NP_001093798.1
    XP_005221702.1
    XP_010815145.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100328.1 → NP_001093798.1  ubiquitin thioesterase otulin

      See identical proteins and their annotated locations for NP_001093798.1

      Status: PROVISIONAL

      Source sequence(s)
      BC148093
      UniProtKB/TrEMBL
      A6QLU9, F6Q7W7
      Related
      ENSBTAP00000004138.6, ENSBTAT00000004138.7
      Conserved Domains (1) summary
      pfam16218
      Location:81 → 344
      Peptidase_C101; Peptidase family C101

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      58490255..58526786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005221645.5 → XP_005221702.1  ubiquitin thioesterase otulin isoform X2

      UniProtKB/TrEMBL
      F6Q7W7
      Conserved Domains (1) summary
      pfam16218
      Location:27 → 290
      Peptidase_C101; Peptidase family C101

    2. XM_010816843.4 → XP_010815145.1  ubiquitin thioesterase otulin isoform X1

      UniProtKB/TrEMBL
      F6Q7W7
      Conserved Domains (1) summary
      pfam16218
      Location:81 → 302
      Peptidase_C101; Peptidase family C101
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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