AP2A2 adaptor related protein complex 2 subunit alpha 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: AP2A2provided by VGNC
Official Full Name: adaptor related protein complex 2 subunit alpha 2provided by VGNC
Primary source: VGNC:VGNC:25984
See related: Ensembl:ENSBTAG00000009915
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 29

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	29	NC_037356.1 (50417491..50484914, complement)

Chromosome 29 - NC_037356.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_23449-23450:1027106382:1 (e-PCR)
- UniSTS:268701

ha2170 (e-PCR)
- UniSTS:515496

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of membrane coat	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: AP-2 complex subunit alpha-2

Names: 100 kDa coated vesicle protein C; adapter-related protein complex 2 alpha-2 subunit; adapter-related protein complex 2 subunit alpha-2; adaptor protein complex AP-2 subunit alpha-2; adaptor related protein complex 2 alpha 2 subunit; alpha-adaptin C; alpha2-adaptin; clathrin assembly protein complex 2 alpha-C large chain; plasma membrane adaptor HA2/AP2 adaptin alpha C subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001075702.1 → NP_001069170.1 AP-2 complex subunit alpha-2

See identical proteins and their annotated locations for NP_001069170.1

Status: PROVISIONAL

Source sequence(s)

BC120121

UniProtKB/Swiss-Prot

Q0VCK5

UniProtKB/TrEMBL

A0AAF7ABZ8

Conserved Domains (4) summary

pfam01602
Location:29 → 591

Adaptin_N; Adaptin N terminal region

pfam02296
Location:825 → 933

Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain

pfam02883
Location:712 → 818

Alpha_adaptinC2; Adaptin C-terminal domain

sd00044
Location:332 → 355

HEAT; HEAT repeat [structural motif]