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    APLF aprataxin and PNKP like factor [ Bos taurus (domestic cattle) ]

    Gene ID: 507989, updated on 30-Jan-2025

    Summary

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    Official Symbol
    APLFprovided by VGNC
    Official Full Name
    aprataxin and PNKP like factorprovided by VGNC
    Primary source
    VGNC:VGNC:59203
    See related
    BGD:BT21362; EnsemblRapid:ENSBTAG00070029028
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See APLF in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (66865116..66958574)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene pleckstrin Neighboring gene F-box protein 48 Neighboring gene prokineticin receptor 1 Neighboring gene Rho GTPase activating protein 25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152013

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aprataxin and PNK-like factor
    Names
    aprataxin- and PNK-like factor
    apurinic-apyrimidinic endonuclease APLF
    NP_001071342.1
    XP_005212902.1
    XP_059747109.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077874.1 → NP_001071342.1  aprataxin and PNK-like factor

      See identical proteins and their annotated locations for NP_001071342.1

      Status: PROVISIONAL

      Source sequence(s)
      BC126691
      UniProtKB/Swiss-Prot
      A0JNH9
      UniProtKB/TrEMBL
      A0AAA9TLQ3
      Related
      ENSBTAP00070040106.1, ENSBTAT00070066032.1
      Conserved Domains (1) summary
      pfam10283
      Location:393 → 414
      zf-CCHH; Zinc-finger (CX5CX6HX5H) motif

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      66865116..66958574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059891126.1 → XP_059747109.1  aprataxin and PNK-like factor isoform X2

      UniProtKB/TrEMBL
      A0AAA9TGZ8, A0AAA9TLQ3
      Related
      ENSBTAP00070040078.1, ENSBTAT00070066007.1

    2. XM_005212845.5 → XP_005212902.1  aprataxin and PNK-like factor isoform X1

      UniProtKB/TrEMBL
      A0AAA9TLQ3, G3MZQ3
      Related
      ENSBTAP00070040072.1, ENSBTAT00070066001.1
      Conserved Domains (2) summary
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam10283
      Location:417 → 438
      zf-CCHH; Zinc-finger (CX5CX6HX5H) motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JNH9.1 GenPept UniProtKB/Swiss-Prot:A0JNH9

    Gene LinkOut

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    Research Materials