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    MTA2 metastasis associated 1 family member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 515389, updated on 30-Jan-2025

    Summary

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    Official Symbol
    MTA2provided by VGNC
    Official Full Name
    metastasis associated 1 family member 2provided by VGNC
    Primary source
    VGNC:VGNC:31714
    See related
    BGD:BT16205; EnsemblRapid:ENSBTAG00070030708
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MTA2 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (40938953..40947354, complement)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene citrate synthase lysine methyltransferase Neighboring gene uncharacterized LOC132344205 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene EMAP like 3 Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene retinal outer segment membrane protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metastasis-associated protein MTA2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075712.1 → NP_001069180.1  metastasis-associated protein MTA2

      See identical proteins and their annotated locations for NP_001069180.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114673
      UniProtKB/TrEMBL
      F6RJB2, Q1RMW3
      Related
      ENSBTAP00070042331.1, ENSBTAT00070069513.1
      Conserved Domains (6) summary
      smart00717
      Location:266 → 313
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:267 → 312
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:363 → 413
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:366 → 421
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:3 → 168
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:147 → 198
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40938953..40947354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024987142.2 → XP_024842910.1  metastasis-associated protein MTA2 isoform X1

      Conserved Domains (3) summary
      cd11661
      Location:132 → 177
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:228 → 278
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      pfam01448
      Location:12 → 63
      ELM2; ELM2 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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