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    GAK cyclin G associated kinase [ Bos taurus (domestic cattle) ]

    Gene ID: 511296, updated on 1-Jan-2025

    Summary

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    Official Symbol
    GAKprovided by VGNC
    Official Full Name
    cyclin G associated kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:29211
    See related
    BGD:BT22912; Ensembl:ENSBTAG00000019188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GAK in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (117431903..117479764)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene alpha-L-iduronidase Neighboring gene solute carrier family 26 member 1 Neighboring gene diacylglycerol kinase theta Neighboring gene transmembrane protein 175 Neighboring gene uncharacterized LOC132345559 Neighboring gene complexin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC127293

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin coat disassembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-G-associated kinase
    NP_001039549.1
    XP_005208340.2
    XP_010804660.2
    XP_010804661.2
    XP_024848920.1
    XP_024848921.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046084.2 → NP_001039549.1  cyclin-G-associated kinase

      See identical proteins and their annotated locations for NP_001039549.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105343
      UniProtKB/TrEMBL
      F1MIB2, Q2KJH2
      Related
      ENSBTAP00000025537.5, ENSBTAT00000025537.6
      Conserved Domains (4) summary
      cd06257
      Location:1216 → 1256
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39 → 320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:559 → 697
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      117431903..117479764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010806359.4 → XP_010804661.2  cyclin-G-associated kinase isoform X3

      UniProtKB/TrEMBL
      F1MIB2
      Conserved Domains (2) summary
      cd14036
      Location:39 → 320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:559 → 697
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    2. XM_010806358.4 → XP_010804660.2  cyclin-G-associated kinase isoform X1

      UniProtKB/TrEMBL
      F1MIB2
      Conserved Domains (4) summary
      cd06257
      Location:1128 → 1168
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:471 → 609
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:1 → 232
      PKc_like; Protein Kinases, catalytic domain
      cl28033
      Location:659 → 1048
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    3. XM_024993153.2 → XP_024848921.1  cyclin-G-associated kinase isoform X2

      UniProtKB/TrEMBL
      F1MIB2
      Conserved Domains (4) summary
      cd06257
      Location:1094 → 1134
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:437 → 575
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:2 → 198
      PKc_like; Protein Kinases, catalytic domain
      cl28033
      Location:625 → 1014
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    4. XM_024993152.2 → XP_024848920.1  cyclin-G-associated kinase isoform X2

      UniProtKB/TrEMBL
      F1MIB2
      Conserved Domains (4) summary
      cd06257
      Location:1094 → 1134
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:437 → 575
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:2 → 198
      PKc_like; Protein Kinases, catalytic domain
      cl28033
      Location:625 → 1014
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    5. XM_005208283.3 → XP_005208340.2  cyclin-G-associated kinase isoform X2

      UniProtKB/TrEMBL
      F1MIB2
      Conserved Domains (4) summary
      cd06257
      Location:1094 → 1134
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam10409
      Location:437 → 575
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl21453
      Location:2 → 198
      PKc_like; Protein Kinases, catalytic domain
      cl28033
      Location:625 → 1014
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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