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    UROS uroporphyrinogen III synthase [ Bos taurus (domestic cattle) ]

    Gene ID: 613425, updated on 1-Jan-2025

    Summary

    Official Symbol
    UROSprovided by VGNC
    Official Full Name
    uroporphyrinogen III synthaseprovided by VGNC
    Primary source
    VGNC:VGNC:36702
    See related
    BGD:BT29419; Ensembl:ENSBTAG00000005791
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    UROIIIS
    Orthologs
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    Genomic context

    See UROS in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (45300454..45324547, complement)

    Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene erythroid differentiation regulatory factor 1 Neighboring gene uncharacterized LOC101902174 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene DEAH-box helicase 32 (putative) Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

    Expression

    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Pathways from PubChem

    General protein information

    Preferred Names
    uroporphyrinogen-III synthase
    Names
    hydroxymethylbilane hydrolyase, cyclizing
    uroporphyrinogen III synthase (congenital erythropoietic porphyria)
    uroporphyrinogen-III cosynthetase
    NP_001178298.1
    XP_005225913.1
    XP_005225914.1
    XP_059737915.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191369.2NP_001178298.1  uroporphyrinogen-III synthase

      See identical proteins and their annotated locations for NP_001178298.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000026
      UniProtKB/TrEMBL
      F6QDV4
      Related
      ENSBTAP00000007615.5, ENSBTAT00000007615.7
      Conserved Domains (1) summary
      cd06578
      Location:3255
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      45300454..45324547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005225856.5XP_005225913.1  uroporphyrinogen-III synthase isoform X1

      See identical proteins and their annotated locations for XP_005225913.1

      UniProtKB/TrEMBL
      F6QDV4
      Conserved Domains (1) summary
      cd06578
      Location:3255
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...
    2. XM_005225857.5XP_005225914.1  uroporphyrinogen-III synthase isoform X1

      See identical proteins and their annotated locations for XP_005225914.1

      UniProtKB/TrEMBL
      F6QDV4
      Conserved Domains (1) summary
      cd06578
      Location:3255
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...
    3. XM_059881932.1XP_059737915.1  uroporphyrinogen-III synthase isoform X2

      UniProtKB/TrEMBL
      A8R437

    RNA

    1. XR_003032734.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001110086.1: Suppressed sequence

      Description
      NM_001110086.1: This RefSeq was suppressed temporarily because the length of the annotated CDS is shorter than that of putative orthologs.