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    IQGAP3 IQ motif containing GTPase activating protein 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 505886, updated on 1-Jan-2025

    Summary

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    Official Symbol
    IQGAP3provided by VGNC
    Official Full Name
    IQ motif containing GTPase activating protein 3provided by VGNC
    Primary source
    VGNC:VGNC:30260
    See related
    Ensembl:ENSBTAG00000006882
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See IQGAP3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (14259683..14299014)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene G-patch domain containing 4 Neighboring gene NAD(P)HX epimerase Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene 60S ribosomal protein L27a pseudogene Neighboring gene uncharacterized LOC132344829

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139205

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic actomyosin contractile ring assembly actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras GTPase-activating-like protein IQGAP3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098880.1 → NP_001092350.1  ras GTPase-activating-like protein IQGAP3

      See identical proteins and their annotated locations for NP_001092350.1

      Status: PROVISIONAL

      Source sequence(s)
      BC146242
      UniProtKB/TrEMBL
      A0AAF6DLK2, A6H7H0, E1B946
      Related
      ENSBTAP00000043999.5, ENSBTAT00000046733.5
      Conserved Domains (6) summary
      smart00015
      Location:767 → 784
      IQ; Calmodulin-binding motif
      smart00323
      Location:980 → 1331
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:35 → 147
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00201
      Location:674 → 701
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam03836
      Location:1452 → 1558
      RasGAP_C; RasGAP C-terminus
      cl02569
      Location:991 → 1340
      RasGAP; Ras GTPase Activating Domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      14259683..14299014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024986230.2 → XP_024841998.1  ras GTPase-activating-like protein IQGAP3 isoform X2

      UniProtKB/TrEMBL
      A0AAA9S506
      Related
      ENSBTAP00000081019.1, ENSBTAT00000111739.1
      Conserved Domains (4) summary
      cd00201
      Location:674 → 701
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl02569
      Location:991 → 1340
      RasGAP; Ras GTPase Activating Domain
      cl27227
      Location:865 → 1614
      RasGAP_C; RasGAP C-terminus
      cl27381
      Location:738 → 961
      Myosin_head; Myosin head (motor domain)

    2. XM_059882607.1 → XP_059738590.1  ras GTPase-activating-like protein IQGAP3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9S506
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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