GUCY2D guanylate cyclase 2D, retinal [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: GUCY2Dprovided by VGNC
Official Full Name: guanylate cyclase 2D, retinalprovided by VGNC
Primary source: VGNC:VGNC:29723
See related: BGD:BT20260; Ensembl:ENSBTAG00000008773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 19

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (27662514..27676988)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The findings define a new regulatory mechanism of the ROS-GC system that affects visual transduction and is likely to affect the course of retinal diseases caused by cGMP toxicity.
Title: Bicarbonate Modulates Photoreceptor Guanylate Cyclase (ROS-GC) Catalytic Activity.
The coexpression of ROS-GC1 and its activators in spermatozoa suggests that the Ca(2+)-modulated ROS-GC1 transduction system may be a part of the fertilization machinery
Title: Rod outer segment membrane guanylate cyclase type 1 (ROS-GC1) calcium-modulated transduction system in the sperm.
The Tyr965-Asn981 region of rod outer segment membrane guanylate cyclase type 1 (ROS-GC1) houses both the structural and functional components that mediate guanylate cyclase activating protein type 2 (GCAP2) regulation.
Title: The calcium-sensor guanylate cyclase activating protein type 2 specific site in rod outer segment membrane guanylate cyclase type 1.
Mg(2+) binding to GCAPs is critical for setting the actual dynamic range of RetGC regulation by GCAPs at physiological levels of free Ca(2+)
Title: Guanylyl cyclase-activating proteins (GCAPs) are Ca2+/Mg2+ sensors: implications for photoreceptor guanylyl cyclase (RetGC) regulation in mammalian photoreceptors.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peptide receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in receptor guanylyl cyclase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: retinal guanylyl cyclase 1

Names: GC-E; RETGC-1; ROS-GC; guanylate cyclase 2D, membrane (retina-specific); guanylate cyclase E; rod outer segment membrane guanylate cyclase

NP_776973.2

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174548.4 → NP_776973.2 retinal guanylyl cyclase 1 precursor

See identical proteins and their annotated locations for NP_776973.2

Status: VALIDATED

Source sequence(s)

NKLS02000019, U77095

UniProtKB/Swiss-Prot

O02809, P55203

UniProtKB/TrEMBL

F1MY40

Related

ENSBTAP00000011564.3, ENSBTAT00000011564.4

Conserved Domains (7) summary

cd06371
Location:60 → 436

PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues

smart00044
Location:851 → 1040

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14043
Location:542 → 816

PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D

pfam00211
Location:876 → 1063

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:77 → 413

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:825 → 870

HNOBA; Heme NO binding associated

pfam07714
Location:560 → 803

Pkinase_Tyr; Protein tyrosine kinase