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    LTB4R leukotriene B4 receptor [ Homo sapiens (human) ]

    Gene ID: 1241, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LTB4Rprovided by HGNC
    Official Full Name
    leukotriene B4 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:6713
    See related
    Ensembl:ENSG00000213903 MIM:601531; AllianceGenome:HGNC:6713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BLT1; BLTR; P2Y7; GPR16; LTBR1; P2RY7; CMKRL1; LTB4R1
    Summary
    Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in skin (RPKM 33.9), esophagus (RPKM 9.6) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LTB4R in Genome Data Viewer
    Location:
    14q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24311502..24318036)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18509845..18516371)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24780708..24787242)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NOP9 nucleolar protein Neighboring gene dehydrogenase/reductase 1 Neighboring gene nonconserved acetylation island sequence 81 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5636 Neighboring gene cell death inducing DFFA like effector b Neighboring gene leukotriene B4 receptor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24785286-24785786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24790818-24791777 Neighboring gene adenylate cyclase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5639 Neighboring gene Sharpr-MPRA regulatory region 10023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8216 Neighboring gene receptor interacting serine/threonine kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural basis of leukotriene B4 receptor 1 activation. Wang N, et al. Nat Commun, 2022 Mar 3. PMID 35241677, Free PMC Article
    2. Role of leukotriene B₄ receptor signaling in human preadipocyte differentiation. Hirata K, et al. Biochem Biophys Res Commun, 2012 Dec 14. PMID 23137534
    3. Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival. Stankova J, et al. J Immunol, 2002 Apr 1. PMID 11907121
    4. Subcellular localization of leukotriene receptors in human endothelial cells. Johansson AS, et al. Exp Cell Res, 2010 Oct 15. PMID 20688055
    5. In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor. Yokomizo T, et al. Adv Exp Med Biol, 2002. PMID 12664610

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis of leukotriene B4 receptor 1 activation.
      Title: Structural basis of leukotriene B4 receptor 1 activation.
    2. SPM Receptor Expression and Localization in Irradiated Salivary Glands.
      Title: SPM Receptor Expression and Localization in Irradiated Salivary Glands.
    3. Structural insights on ligand recognition at the human leukotriene B4 receptor 1.
      Title: Structural insights on ligand recognition at the human leukotriene B4 receptor 1.
    4. The role of the LTB4-BLT1 axis in health and disease.
      Title: The role of the LTB4-BLT1 axis in health and disease.
    5. A regulatory role of scavenger receptor class B type 1 in endocytosis and lipid droplet formation induced by liposomes containing phosphatidylethanolamine in HEK293T cells.
      Title: A regulatory role of scavenger receptor class B type 1 in endocytosis and lipid droplet formation induced by liposomes containing phosphatidylethanolamine in HEK293T cells.
    6. Individuals with nodules showed significantly higher levels of TxB2 and LTB4 than healthy controls, whereas significant differences in LTB4 levels were observed between individuals with unencapsulated dirofilariosis worms and healthy controls.
      Title: A possible relationship between Thromboxane B2 and Leukotriene B4 and the encapsulation of Dirofilaria repens worms in human subcutaneous dirofilariasis.
    7. Trichomonas vaginalis-derived secretory products (TvSP) induces protein O-GlcNAcylation and O-GlcNAc transferase (OGT) expression in mast cells, which is prevented by LTB4 receptor (BLT1) siRNA. TvSP-induced migration, ROS generation, and IL-8 release are suppressed by OGT inhibitor or OGT siRNA. These results suggest that BLT1-mediated OGlcNAcylation is important for mast cell activation during trichomoniasis.
      Title: BLT1-mediated O-GlcNAcylation is required for NOX2-dependent migration, exocytotic degranulation and IL-8 release of human mast cell induced by Trichomonas vaginalis-secreted LTB(4).
    8. analysis of leukotriene B4 (LTB4) receptor BLT1 bound with BIIL260, a chemical bearing a benzamidine moiety, reveals that it is fixed in the inactive state, and the transmembrane helices cannot change their conformations to form the active state
      Title: Na(+)-mimicking ligands stabilize the inactive state of leukotriene B(4) receptor BLT1.
    9. fact, leukotriene B4 (LTB4) is an eicosanoid lipid derivative of arachidonic acid, which primarily binds itself to the high-affinity G protein-coupled receptor BLT1. BLT1 plays an indispensable role in atherosclerosis. Hence, the BLT1 antagonist might have a therapeutic role in treating atherosclerosis. [review]
      Title: BLT1: a promising therapeutic approach for atherosclerosis.
    10. A novel regulatory mechanism for SNAP23-dependent mast cell activation of T. vaginalis-secreted LTB4 involving surface trafficking of BLT1.
      Title: SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4.
    Submit: New GeneRIF Correction See all GeneRIFs (58)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene B4 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleotide binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in leukotriene signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    leukotriene B4 receptor 1
    Names
    G protein-coupled receptor 16
    LTB4-R 1
    LTB4-R1
    P2Y purinoceptor 7
    chemoattractant receptor-like 1
    chemokine receptor-like 1
    purinergic receptor P2Y, G-protein coupled, 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143919.3 → NP_001137391.1  leukotriene B4 receptor 1

      See identical proteins and their annotated locations for NP_001137391.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AL096870, BQ182452, D89079
      Consensus CDS
      CCDS9626.1
      UniProtKB/Swiss-Prot
      Q13305, Q15722, Q53XV5, Q92641, Q9BSU5
      Related
      ENSP00000307445.3, ENST00000345363.8
      Conserved Domains (1) summary
      pfam00001
      Location:35 → 285
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_181657.3 → NP_858043.1  leukotriene B4 receptor 1

      See identical proteins and their annotated locations for NP_858043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AL096870, BQ182452
      Consensus CDS
      CCDS9626.1
      UniProtKB/Swiss-Prot
      Q13305, Q15722, Q53XV5, Q92641, Q9BSU5
      Related
      ENSP00000380008.4, ENST00000396789.4
      Conserved Domains (1) summary
      pfam00001
      Location:35 → 285
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      24311502..24318036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654722.1 Reference GRCh38.p14 PATCHES

      Range
      612480..619014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      18509845..18516371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15722.2 GenPept UniProtKB/Swiss-Prot:Q15722

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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