ROPN1B rhophilin associated tail protein 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: ROPN1Bprovided by HGNC
Official Full Name: rhophilin associated tail protein 1Bprovided by HGNC
Primary source: HGNC:HGNC:31927
See related: Ensembl:ENSG00000114547 AllianceGenome:HGNC:31927
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Enables protein heterodimerization activity. Predicted to be involved in several processes, including flagellated sperm motility; protein localization to cilium; and sperm capacitation. Located in cytoplasm and motile cilium. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis (RPKM 113.4) See more
Orthologs: all
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Genomic context

Location:: 3q21.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (125969178..125983454)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (128701549..128715814)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (125688021..125702297)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor complex adaptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in acrosome reaction	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cilium organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoskeleton-dependent cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in flagellated sperm motility	TAS Traceable Author Statement more info	PubMed
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	NAS Non-traceable Author Statement more info	PubMed
involved_in protein localization to cilium	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm capacitation	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ropporin-1B

Names: AKAP-binding sperm protein ropporin; rhophilin-associated protein 1B; ropporin, rhophilin associated protein 1B; testis tissue sperm-binding protein Li 83P

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012337.3 → NP_001012337.1 ropporin-1B

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AF231410, HY006578

Consensus CDS

CCDS33841.1

UniProtKB/Swiss-Prot

D3DNA6, Q96BM7, Q9BZX4

UniProtKB/TrEMBL

A0A140VKG6

Related

ENSP00000251776.4, ENST00000251776.8

Conserved Domains (1) summary

cl02594
Location:12 → 44

DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
NM_001308313.2 → NP_001295242.1 ropporin-1B

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC141849, DC397187

Consensus CDS

CCDS33841.1

UniProtKB/Swiss-Prot

D3DNA6, Q96BM7, Q9BZX4

UniProtKB/TrEMBL

A0A140VKG6

Related

ENSP00000426271.1, ENST00000514116.6

Conserved Domains (1) summary

cl02594
Location:12 → 44

DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

125969178..125983454

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006713513.4 → XP_006713576.1 ropporin-1B isoform X1

UniProtKB/Swiss-Prot

D3DNA6, Q96BM7, Q9BZX4

UniProtKB/TrEMBL

A0A140VKG6

Conserved Domains (1) summary

cl02594
Location:12 → 44

DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
XM_005247138.4 → XP_005247195.1 ropporin-1B isoform X2

UniProtKB/Swiss-Prot

Q9BZX4

Related

ENSP00000421662.1, ENST00000505382.5