GBP2 guanylate binding protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GBP2provided by HGNC
Official Full Name: guanylate binding protein 2provided by HGNC
Primary source: HGNC:HGNC:4183
See related: Ensembl:ENSG00000162645 MIM:600412; AllianceGenome:HGNC:4183
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]
Expression: Ubiquitous expression in appendix (RPKM 36.9), urinary bladder (RPKM 31.7) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 1p22.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (89106132..89126114, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (88949485..88969475, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (89571815..89591797, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Weighted gene co-expression network analysis identified GBP2 connected to PPARalpha activity and liver cancer.
Title: Weighted gene co-expression network analysis identified GBP2 connected to PPARα activity and liver cancer.
The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.
Title: The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.
GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.
Title: GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.
GBP2 promotes M1 macrophage polarization by activating the notch1 signaling pathway in diabetic nephropathy.
Title: GBP2 promotes M1 macrophage polarization by activating the notch1 signaling pathway in diabetic nephropathy.
Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Ppargamma-CD36 axis.
Title: Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.
GBP2 promotes clear cell renal cell carcinoma progression through immune infiltration and regulation of PDL1 expression via STAT1 signaling.
Title: GBP2 promotes clear cell renal cell carcinoma progression through immune infiltration and regulation of PD‑L1 expression via STAT1 signaling.
Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue.
Title: Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue.
Guanine nucleotide-binding protein 2, GNBP2, accelerates the progression of clear cell renal cell carcinoma via regulation of STAT3 signaling transduction pathway.
Title: Guanine nucleotide-binding protein 2, GNBP2, accelerates the progression of clear cell renal cell carcinoma via regulation of STAT3 signaling transduction pathway.
GBP2 serves as a novel prognostic biomarker and potential immune microenvironment indicator in renal cell carcinoma.
Title: GBP2 serves as a novel prognostic biomarker and potential immune microenvironment indicator in renal cell carcinoma.
GBP2 acts as a member of the interferon signalling pathway in lupus nephritis.
Title: GBP2 acts as a member of the interferon signalling pathway in lupus nephritis.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of guanylate binding protein 2, interferon-inducible (GBP2) in primary human brain microvascular endothelial cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GBP2_2313 (e-PCR)
- UniSTS:280691

SHGC-75111 (e-PCR)
- UniSTS:41845

WI-9135 (e-PCR)
- UniSTS:33149

G59213 (e-PCR)
- UniSTS:136386

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in cytolysis in another organism	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to protozoan	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of AIM2 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of pyroptotic inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanylate-binding protein 2

Names: GTP-binding protein 2; guanine nucleotide-binding protein 2; guanylate binding protein 2, interferon-inducible; interferon-induced guanylate-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.