Ube2g1 ubiquitin-conjugating enzyme E2G 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2g1provided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2G 1provided by MGI
Primary source: MGI:MGI:1914378
See related: Ensembl:ENSMUSG00000020794 AllianceGenome:MGI:1914378
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700059C12Rik; D130023C12Rik
Summary: Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in protein K48-linked ubiquitination. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; liver and biliary system; and sensory organ. Orthologous to human UBE2G1 (ubiquitin conjugating enzyme E2 G1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E14 (RPKM 13.9), whole brain E14.5 (RPKM 13.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 44.42 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (72498087..72577307)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (72607261..72686481)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW552068 (e-PCR)
- UniSTS:180246

NoName (e-PCR)
- UniSTS:488747

AU014992 (e-PCR)
- UniSTS:208701

D11Jcs1 (e-PCR), detects polymorphism
- UniSTS:461956

RH136096 (e-PCR)
- UniSTS:210091

RH71332 (e-PCR)
- UniSTS:25568

Ube2g1 (e-PCR), detects polymorphism
- UniSTS:527596

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 G1

Names: E2 ubiquitin-conjugating enzyme G1; E217K; UBC7; ubiquitin carrier protein G1; ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans); ubiquitin-protein ligase G1

NP_080261.2

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025985.4 → NP_080261.2 ubiquitin-conjugating enzyme E2 G1

Status: VALIDATED

Source sequence(s)

AK167472, AL808023, DV657669

Consensus CDS

CCDS36217.1

UniProtKB/Swiss-Prot

P62254, Q4VAA6

UniProtKB/TrEMBL

Q5F239

Related

ENSMUSP00000021148.7, ENSMUST00000021148.13

Conserved Domains (1) summary

pfam00179
Location:10 → 161

UQ_con; Ubiquitin-conjugating enzyme