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    RAB27B RAB27B, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 5874, updated on 10-Dec-2024

    Summary

    Official Symbol
    RAB27Bprovided by HGNC
    Official Full Name
    RAB27B, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9767
    See related
    Ensembl:ENSG00000041353 MIM:603869; AllianceGenome:HGNC:9767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C25KG
    Summary
    Enables guanyl ribonucleotide binding activity; myosin V binding activity; and protein domain specific binding activity. Involved in multivesicular body sorting pathway and positive regulation of exocytosis. Located in Golgi stack and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach (RPKM 15.0), prostate (RPKM 9.9) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RAB27B in Genome Data Viewer
    Location:
    18q21.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (54717857..54895516)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (54920965..55098601)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (52385088..52562747)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904308 Neighboring gene DYNAP pseuodgene 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:52274507-52275298 Neighboring gene dynactin associated protein Neighboring gene Sharpr-MPRA regulatory region 14135 Neighboring gene Sharpr-MPRA regulatory region 5858 Neighboring gene ribosomal protein SA pseudogene 57 Neighboring gene Sharpr-MPRA regulatory region 14713 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:52573135-52573366 Neighboring gene coiled-coil domain containing 68 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:52635171-52636370 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:52642293-52643492 Neighboring gene microtubule associated protein 1 light chain 3 pseudogene Neighboring gene uncharacterized LOC107985125

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity  
    enables GDP binding PubMed 
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables membrane scission GTPase motor activity  
    enables myosin V binding PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal protein transport  
    involved_in exocytosis  
    involved_in multivesicular body sorting pathway PubMed 
    involved_in positive regulation of exocytosis  
    involved_in positive regulation of exocytosis PubMed 
    involved_in synaptic vesicle endocytosis  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi stack PubMed 
    is_active_in apical plasma membrane  
    located_in axon cytoplasm  
    is_active_in exocytic vesicle  
    located_in extracellular exosome PubMed 
    located_in late endosome PubMed 
    is_active_in melanosome  
    located_in melanosome PubMed 
    located_in multivesicular body membrane PubMed 
    located_in plasma membrane  
    located_in platelet dense granule membrane  
    is_active_in secretory granule  
    located_in synaptic vesicle membrane  
    located_in trans-Golgi network transport vesicle PubMed 
    located_in zymogen granule membrane  

    General protein information

    Preferred Names
    ras-related protein Rab-27B
    NP_001362256.1
    NP_004154.2
    XP_006722581.1
    XP_016881402.1
    XP_016881403.1
    XP_024307000.1
    XP_047293681.1
    XP_047293682.1
    XP_054174925.1
    XP_054174926.1
    XP_054174927.1
    XP_054174928.1
    XP_054174929.1
    XP_054174930.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001375327.1NP_001362256.1  ras-related protein Rab-27B

      Status: VALIDATED

      Source sequence(s)
      AC007673, AC098848, AC100776
      Consensus CDS
      CCDS11958.1
      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
      Conserved Domains (1) summary
      cd04127
      Location:6185
      Rab27A; Rab GTPase family 27a (Rab27a)
    2. NM_004163.4NP_004154.2  ras-related protein Rab-27B

      See identical proteins and their annotated locations for NP_004154.2

      Status: VALIDATED

      Source sequence(s)
      AC098848, AF329499
      Consensus CDS
      CCDS11958.1
      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
      Related
      ENSP00000262094.4, ENST00000262094.10
      Conserved Domains (1) summary
      cd04127
      Location:6185
      Rab27A; Rab GTPase family 27a (Rab27a)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      54717857..54895516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025913.2XP_016881402.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
      Conserved Domains (1) summary
      cd04127
      Location:6185
      Rab27A; Rab GTPase family 27a (Rab27a)
    2. XM_006722518.2XP_006722581.1  ras-related protein Rab-27B isoform X2

      See identical proteins and their annotated locations for XP_006722581.1

      Conserved Domains (2) summary
      smart00174
      Location:12170
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cl21455
      Location:6156
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_017025914.2XP_016881403.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
      Conserved Domains (1) summary
      cd04127
      Location:6185
      Rab27A; Rab GTPase family 27a (Rab27a)
    4. XM_047437725.1XP_047293681.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
    5. XM_047437726.1XP_047293682.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
    6. XM_024451232.2XP_024307000.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
      Conserved Domains (1) summary
      cd04127
      Location:6185
      Rab27A; Rab GTPase family 27a (Rab27a)

    RNA

    1. XR_007066208.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      54920965..55098601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318951.1XP_054174926.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
    2. XM_054318950.1XP_054174925.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
    3. XM_054318955.1XP_054174930.1  ras-related protein Rab-27B isoform X2

    4. XM_054318953.1XP_054174928.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
    5. XM_054318952.1XP_054174927.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
    6. XM_054318954.1XP_054174929.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6

    RNA

    1. XR_008485020.1 RNA Sequence

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