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    RPRD1B regulation of nuclear pre-mRNA domain containing 1B [ Homo sapiens (human) ]

    Gene ID: 58490, updated on 10-Dec-2024

    Summary

    Official Symbol
    RPRD1Bprovided by HGNC
    Official Full Name
    regulation of nuclear pre-mRNA domain containing 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:16209
    See related
    Ensembl:ENSG00000101413 MIM:614694; AllianceGenome:HGNC:16209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K-H; CREPT; NET60; C20orf77; Kub5-Hera; dJ1057B20.2
    Summary
    Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in several processes, including RNA polymerase II promoter clearance; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription preinitiation complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 7.4), lymph node (RPKM 7.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RPRD1B in Genome Data Viewer
    Location:
    20q11.23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (38033746..38092364)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (39758090..39816692)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (36662148..36720766)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17853 Neighboring gene TELO2 interacting protein 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36661589-36662184 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36662185-36662780 Neighboring gene uncharacterized LOC124904898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17855 Neighboring gene uncharacterized LOC124904897 Neighboring gene Sharpr-MPRA regulatory region 13539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12896 Neighboring gene RNA, 7SL, cytoplasmic 237, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2618 Neighboring gene uncharacterized LOC124904899 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:36740455-36740954

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ44520, DKFZp434P0735

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II C-terminal domain binding  
    enables RNA polymerase II complex binding  
    enables RNA polymerase II complex binding PubMed 
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    part_of transcription preinitiation complex PubMed 

    General protein information

    Preferred Names
    regulation of nuclear pre-mRNA domain-containing protein 1B
    Names
    Ku70-binding protein 5-Hera
    cell-cycle related and expression-elevated protein in tumor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021215.4 → NP_067038.1  regulation of nuclear pre-mRNA domain-containing protein 1B

      See identical proteins and their annotated locations for NP_067038.1

      Status: VALIDATED

      Source sequence(s)
      AK092567, BC033629, BP359144
      Consensus CDS
      CCDS13301.1
      UniProtKB/Swiss-Prot
      Q1WDE7, Q6PKF4, Q9NQG5
      Related
      ENSP00000362532.4, ENST00000373433.9
      Conserved Domains (2) summary
      cd17012
      Location:3 → 131
      CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
      pfam16566
      Location:178 → 324
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      38033746..38092364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440346.1 → XP_047296302.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1

      UniProtKB/TrEMBL
      A2A2M0
    2. XM_047440347.1 → XP_047296303.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X2

      UniProtKB/TrEMBL
      A2A2M0
      Related
      ENSP00000416420.2, ENST00000449186.2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      39758090..39816692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323787.1 → XP_054179762.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1

      UniProtKB/TrEMBL
      A2A2M0
    2. XM_054323788.1 → XP_054179763.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X2

      UniProtKB/TrEMBL
      A2A2M0
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