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    TMPO thymopoietin [ Homo sapiens (human) ]

    Gene ID: 7112, updated on 3-Dec-2024

    Summary

    Official Symbol
    TMPOprovided by HGNC
    Official Full Name
    thymopoietinprovided by HGNC
    Primary source
    HGNC:HGNC:11875
    See related
    Ensembl:ENSG00000120802 MIM:188380; AllianceGenome:HGNC:11875
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TP; LAP2; CMD1T; LEMD4; PRO0868
    Summary
    Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]
    Expression
    Ubiquitous expression in lymph node (RPKM 23.3), bone marrow (RPKM 19.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMPO in Genome Data Viewer
    Location:
    12q23.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (98515573..98550351)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (98488849..98523648)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (98909351..98944129)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6842 Neighboring gene tRNA-Asp (anticodon GTC) 1-1 Neighboring gene tRNA-Trp (anticodon CCA) 4-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:98902147-98902690 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:98905336-98905836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4753 Neighboring gene TMPO antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:98922080-98922246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6845 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:98987254-98987878 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:98987879-98988503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6847 Neighboring gene peptidylprolyl isomerase A pseudogene 8 Neighboring gene solute carrier family 25 member 3 Neighboring gene small nucleolar RNA, H/ACA box 53

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated lamina-associated polypeptide 2, beta/gamma (LAP2) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    Tat tat Interaction of HIV-1 Tat with lamina-associated polypeptide 2 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC61508

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cadherin binding HDA PubMed 
    enables lamin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    thymopoietin
    Names
    LEM domain containing 4
    lamina-associated polypeptide 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021393.1 RefSeqGene

      Range
      5001..39807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_443

    mRNA and Protein(s)

    1. NM_001032283.3NP_001027454.1  thymopoietin isoform beta

      See identical proteins and their annotated locations for NP_001027454.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 3' end compared to variant 1, resulting in a shorter isoform (beta) with a distinct C-terminus compared to isoform alpha.
      Source sequence(s)
      AA992204, AB209297, AI055921, BC053675, BG676381, BM802949, BQ232508, DB239672
      Consensus CDS
      CCDS31879.1
      UniProtKB/Swiss-Prot
      A2T926, P42167, Q14861
      Related
      ENSP00000450627.1, ENST00000556029.6
      Conserved Domains (2) summary
      cd12940
      Location:111139
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:349
      Thymopoietin; Thymopoietin protein
    2. NM_001032284.3NP_001027455.1  thymopoietin isoform gamma

      See identical proteins and their annotated locations for NP_001027455.1

      Status: REVIEWED

      Description
      Transcript Variant: This (3) differs at the 3' end compared to variant 1, resulting in a shorter isoform (gamma) with a distinct C-terminus compared to isoform alpha.
      Source sequence(s)
      AA992204, AB209297, AI055921, BG676381, BM802949, BQ232508, DB239672, U09088
      Consensus CDS
      CCDS31880.1
      UniProtKB/TrEMBL
      Q59G12
      Related
      ENSP00000376773.2, ENST00000393053.6
      Conserved Domains (2) summary
      cd12940
      Location:111139
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    3. NM_001307975.2NP_001294904.1  thymopoietin isoform delta

      See identical proteins and their annotated locations for NP_001294904.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs at the 3' end compared to variant 1, resulting in a shorter isoform (delta) with a distinct C-terminus compared to isoform alpha.
      Source sequence(s)
      AA992204, AC013418, BC050383, BC053675, DB239672
      Consensus CDS
      CCDS76589.1
      UniProtKB/TrEMBL
      G5E972, Q59G12
      Related
      ENSP00000340251.5, ENST00000343315.9
      Conserved Domains (2) summary
      cd12940
      Location:111139
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    4. NM_003276.2NP_003267.1  thymopoietin isoform alpha

      See identical proteins and their annotated locations for NP_003267.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (alpha).
      Source sequence(s)
      BM991833, BP423544, BU932961, DB239672, U09086
      Consensus CDS
      CCDS9064.1
      UniProtKB/Swiss-Prot
      P08918, P08919, P42166, Q14860, Q16295
      Related
      ENSP00000266732.4, ENST00000266732.8
      Conserved Domains (3) summary
      cd12940
      Location:111139
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
      pfam11560
      Location:461693
      LAP2alpha; Lamina-associated polypeptide 2 alpha

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      98515573..98550351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269132.5XP_005269189.1  thymopoietin isoform X2

      UniProtKB/TrEMBL
      Q59G12
      Conserved Domains (2) summary
      cd12940
      Location:111139
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:249
      Thymopoietin; Thymopoietin protein
    2. XM_017019914.3XP_016875403.1  thymopoietin isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      98488849..98523648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373116.1XP_054229091.1  thymopoietin isoform X2

      UniProtKB/TrEMBL
      Q59G12
    2. XM_054373115.1XP_054229090.1  thymopoietin isoform X1