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    MIEN1 migration and invasion enhancer 1 [ Homo sapiens (human) ]

    Gene ID: 84299, updated on 10-Dec-2024

    Summary

    Official Symbol
    MIEN1provided by HGNC
    Official Full Name
    migration and invasion enhancer 1provided by HGNC
    Primary source
    HGNC:HGNC:28230
    See related
    Ensembl:ENSG00000141741 MIM:611802; AllianceGenome:HGNC:28230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C35; ORB3; XTP4; RDX12; C17orf37
    Summary
    Involved in negative regulation of apoptotic process; positive regulation of cell migration; and positive regulation of filopodium assembly. Located in cytoplasmic side of plasma membrane and cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon (RPKM 15.4), esophagus (RPKM 14.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MIEN1 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (39728510..39730532, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (40592070..40594092, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37884763..37886785, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37835782-37836282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12103 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:37845149-37846109 Neighboring gene post-GPI attachment to proteins phospholipase 3 Neighboring gene Sharpr-MPRA regulatory region 353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37857299-37857800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37857801-37858300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37861047-37861919 Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37882556-37883528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8463 Neighboring gene microRNA 4728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37896451-37897048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37897647-37898244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12106 Neighboring gene growth factor receptor bound protein 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12108 Neighboring gene IKAROS family zinc finger 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37934634-37934867 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37940879-37941109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12110 Neighboring gene MPRA-validated peak2840 silencer Neighboring gene MPRA-validated peak2841 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37991649-37992148 Neighboring gene keratin 8 pseudogene 34

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    migration and invasion enhancer 1
    Names
    HBV X-transactivated gene 4 protein
    HBV XAg-transactivated protein 4
    protein C17orf37

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330206.2NP_001317135.1  migration and invasion enhancer 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC079199, AY508814, BC063395, CR986467
      Consensus CDS
      CCDS82115.1
      UniProtKB/TrEMBL
      J3KTI2
      Related
      ENSP00000462998.1, ENST00000577810.1
      Conserved Domains (1) summary
      TIGR02174
      Location:2589
      CXXU_selWTH; selT/selW/selH selenoprotein domain
    2. NM_032339.5NP_115715.3  migration and invasion enhancer 1 isoform 1

      See identical proteins and their annotated locations for NP_115715.3

      Status: VALIDATED

      Source sequence(s)
      AC079199, AY508814, BC006006, BC063395
      Consensus CDS
      CCDS11344.1
      UniProtKB/Swiss-Prot
      Q9BRT3
      Related
      ENSP00000377778.3, ENST00000394231.8
      Conserved Domains (1) summary
      TIGR02174
      Location:2595
      CXXU_selWTH; selT/selW/selH selenoprotein domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      39728510..39730532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      40592070..40594092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)