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    NMUR2 neuromedin U receptor 2 [ Homo sapiens (human) ]

    Gene ID: 56923, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NMUR2provided by HGNC
    Official Full Name
    neuromedin U receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:16454
    See related
    Ensembl:ENSG00000132911 MIM:605108; AllianceGenome:HGNC:16454
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FM4; FM-4; TGR1; NMU2R; TGR-1; NMU-R2
    Summary
    This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See NMUR2 in Genome Data Viewer
    Location:
    5q33.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (152391546..152405279, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (152924513..152938245, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (151771107..151784840, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378236 Neighboring gene uncharacterized LOC105378237 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:151724791-151725393 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16530 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82574 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82576 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82580 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82586 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82589 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82596 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82611 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82644 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82645 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82651 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82653 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82661 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82666 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82670/82671 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82672 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82684 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_82696 and experimental_82697 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_82718 and experimental_82721/82722 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82727 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82735 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82741 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82746 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82750 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82779 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82809 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23469 Neighboring gene ribosomal protein L36a pseudogene 20 Neighboring gene NANOG hESC enhancer GRCh37_chr5:151891040-151891644 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83006 Neighboring gene tRNA-Cys (anticodon ACA) 1-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Heterologous expression of G-protein-coupled receptors. Tate CG, et al. Trends Biotechnol, 1996 Nov. PMID 8940772
    2. Ligand-Specific Signaling Profiles and Resensitization Mechanisms of the Neuromedin U2 Receptor. Alhosaini K, et al. Mol Pharmacol, 2018 Jul. PMID 29724789
    3. Identifying a Neuromedin U Receptor 2 Splice Variant and Determining Its Roles in the Regulation of Signaling and Tumorigenesis In Vitro. Lin TY, et al. PLoS One, 2015. PMID 26317338, Free PMC Article
    4. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. Shan L, et al. J Biol Chem, 2000 Dec 15. PMID 11010960
    5. Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. Bhattacharyya S, et al. J Endocrinol, 2004 Oct. PMID 15525579

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD.
      Title: A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD.
    2. Activation by NMU2 is longer lasting if NmS is the ligand.
      Title: Ligand-Specific Signaling Profiles and Resensitization Mechanisms of the Neuromedin U2 Receptor.
    3. NMU might contribute to progression of NMUR2-positive breast cancer
      Title: Oncogenic features of neuromedin U in breast cancer are associated with NMUR2 expression involving crosstalk with members of the WNT signaling pathway.
    4. polymorphisms in the gene may be useful in identifying women at risk for osteoporosis.
      Title: Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.
    5. Study identified a novel NMUR2 splice variant lacking the third exon and able to form heteromeric complexes with NMUR1 and NMUR2 without Neuromedin U (NMU). Its expression can block NMU signaling suppressing then ovarian cancer cells proliferation.
      Title: Identifying a Neuromedin U Receptor 2 Splice Variant and Determining Its Roles in the Regulation of Signaling and Tumorigenesis In Vitro.
    6. A cell-based reporter gene assay has been developed and used for the screening of the human NMU2R agonist.
      Title: Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
    EBI GWAS Catalog
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    EBI GWAS Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellularly calcium-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuromedin U binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuromedin U receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in feeding behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in grooming behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of calcium-mediated signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in reduction of food intake in response to dietary excess IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of smooth muscle contraction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to pain IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    neuromedin-U receptor 2
    Names
    G-protein coupled receptor FM-4
    G-protein coupled receptor TGR-1
    growth hormone secretagogue receptor family, member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020167.5 → NP_064552.3  neuromedin-U receptor 2

      See identical proteins and their annotated locations for NP_064552.3

      Status: REVIEWED

      Source sequence(s)
      AC008571, AI023570, BC067776
      Consensus CDS
      CCDS4321.1
      UniProtKB/Swiss-Prot
      Q7LC54, Q96AM5, Q9GZQ4, Q9NRA6
      Related
      ENSP00000255262.4, ENST00000255262.4
      Conserved Domains (2) summary
      cd15357
      Location:46 → 338
      7tmA_NMU-R2; neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors
      pfam19285
      Location:331 → 397
      NmU-R2_C_term; Neuromedin-U receptor 2, C-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      152391546..152405279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      152924513..152938245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZQ4.2 GenPept UniProtKB/Swiss-Prot:Q9GZQ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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