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    CGN cingulin [ Homo sapiens (human) ]

    Gene ID: 57530, updated on 3-Dec-2024

    Summary

    Official Symbol
    CGNprovided by HGNC
    Official Full Name
    cingulinprovided by HGNC
    Primary source
    HGNC:HGNC:17429
    See related
    Ensembl:ENSG00000143375 MIM:609473; AllianceGenome:HGNC:17429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables cadherin binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to act upstream of or within bicellular tight junction assembly and epithelial cell morphogenesis. Located in bicellular tight junction and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in small intestine (RPKM 30.7), duodenum (RPKM 28.7) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CGN in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151510170..151538692)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150633864..150662396)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151483863..151511168)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151371406-151372128 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151372129-151372850 Neighboring gene proteasome 20S subunit beta 4 Neighboring gene pogo transposable element derived with ZNF domain Neighboring gene Sharpr-MPRA regulatory region 7521 Neighboring gene RNY4 pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151476367-151476867 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:151482940-151483516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151483517-151484092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151485246-151485822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151485823-151486398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151495500-151496035 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:151495990-151497189 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151511530-151512046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151512562-151513077 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:151513078-151513592 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:151519404-151519922 Neighboring gene tuftelin 1 Neighboring gene microRNA 554 Neighboring gene ribosomal protein S10 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ39281, KIAA1319, DKFZp779N1112

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cadherin binding HDA PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in cell junction TAS
    Traceable Author Statement
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020770.3NP_065821.1  cingulin

      See identical proteins and their annotated locations for NP_065821.1

      Status: VALIDATED

      Source sequence(s)
      AF263462, AL365436, BC146657, BC152445, BP331021, CN359389
      Consensus CDS
      CCDS999.1
      UniProtKB/Swiss-Prot
      A6H8L3, A7MD22, Q5T386, Q9NR25, Q9P2M7
      UniProtKB/TrEMBL
      B9EK46
      Related
      ENSP00000271636.7, ENST00000271636.12
      Conserved Domains (1) summary
      cl25732
      Location:3681152
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      151510170..151538692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245365.6XP_005245422.1  cingulin isoform X1

      See identical proteins and their annotated locations for XP_005245422.1

      UniProtKB/Swiss-Prot
      A6H8L3, A7MD22, Q5T386, Q9NR25, Q9P2M7
      UniProtKB/TrEMBL
      B9EK46
      Conserved Domains (1) summary
      cl25732
      Location:3681152
      SMC_N; RecF/RecN/SMC N terminal domain

    RNA

    1. XR_921902.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      150633864..150662396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337817.1XP_054193792.1  cingulin isoform X1

      UniProtKB/Swiss-Prot
      A6H8L3, A7MD22, Q5T386, Q9NR25, Q9P2M7
      UniProtKB/TrEMBL
      B9EK46

    RNA

    1. XR_008486119.1 RNA Sequence