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    CDX4 caudal type homeobox 4 [ Homo sapiens (human) ]

    Gene ID: 1046, updated on 10-Dec-2024

    Summary

    Official Symbol
    CDX4provided by HGNC
    Official Full Name
    caudal type homeobox 4provided by HGNC
    Primary source
    HGNC:HGNC:1808
    See related
    Ensembl:ENSG00000131264 MIM:300025; AllianceGenome:HGNC:1808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of a small subfamily of homeobox containing transcription factors. The encoded protein may regulate homeobox gene expression during anteroposterior patterning and hematopoiesis. [provided by RefSeq, Aug 2012]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See CDX4 in Genome Data Viewer
    Location:
    Xq13.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (73447053..73455171)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (71880436..71888553)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (72666889..72675007)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene 8 Neighboring gene RNA, U6 small nuclear 1044, pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chrX:72666583-72667248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:72667249-72667913 Neighboring gene NANOG hESC enhancer GRCh37_chrX:72673827-72674431 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:72701495-72702694 Neighboring gene mortality factor 4 like 1 pseudogene 6 Neighboring gene mitogen-activated protein kinase kinase 4 pseudogene 1 Neighboring gene ribosomal protein L7 pseudogene 53

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin  
    is_active_in nucleus  

    General protein information

    Preferred Names
    homeobox protein CDX-4
    Names
    caudal type homeobox transcription factor 4
    caudal-type homeobox protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005193.2NP_005184.1  homeobox protein CDX-4

      See identical proteins and their annotated locations for NP_005184.1

      Status: REVIEWED

      Source sequence(s)
      AL450108
      Consensus CDS
      CCDS14424.1
      UniProtKB/Swiss-Prot
      A1A513, O14627, Q5JS20
      Related
      ENSP00000362613.1, ENST00000373514.3
      Conserved Domains (2) summary
      pfam00046
      Location:177229
      Homeobox; Homeobox domain
      pfam04731
      Location:13162
      Caudal_act; Caudal like protein activation region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      73447053..73455171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      71880436..71888553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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