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    TAS2R1 taste 2 receptor member 1 [ Homo sapiens (human) ]

    Gene ID: 50834, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TAS2R1provided by HGNC
    Official Full Name
    taste 2 receptor member 1provided by HGNC
    Primary source
    HGNC:HGNC:14909
    See related
    Ensembl:ENSG00000169777 MIM:604796; AllianceGenome:HGNC:14909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T2R1; TRB7
    Summary
    This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
    Orthologs
    mouse all
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    Genomic context

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    See TAS2R1 in Genome Data Viewer
    Location:
    5p15.31-p15.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (9627347..9903876, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (9567134..9843682, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (9627459..9903988, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 123 Neighboring gene small nucleolar RNA host gene 18 Neighboring gene uncharacterized LOC101929359 Neighboring gene uncharacterized LOC124900938 Neighboring gene long intergenic non-protein coding RNA 2112 Neighboring gene uncharacterized LOC105374649 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:9774748-9775340 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:9775483-9776682 Neighboring gene RNA, 5S ribosomal pseudogene 177 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:9832529-9833029 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:9832028-9832528 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:9833753-9834254 Neighboring gene long intergenic non-protein coding RNA 2221 Neighboring gene NANOG hESC enhancer GRCh37_chr5:9895310-9895811 Neighboring gene uncharacterized LOC107986405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:9944391-9944892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:9944893-9945392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15911 Neighboring gene uncharacterized LOC124900939

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19. Watanabe LM, et al. Clinics (Sao Paulo), 2020. PMID 32876108, Free PMC Article
    2. Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells. Sharma P, et al. Am J Physiol Lung Cell Mol Physiol, 2016 Feb 15. PMID 26684251, Free PMC Article
    3. Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs). Singh N, et al. J Biol Chem, 2011 Oct 14. PMID 21852241, Free PMC Article
    4. Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies. Dai W, et al. J Recept Signal Transduct Res, 2011 Jun. PMID 21619450
    5. Bitter taste receptor T2R1 is activated by dipeptides and tripeptides. Upadhyaya J, et al. Biochem Biophys Res Commun, 2010 Jul 23. PMID 20599705

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment.
      Title: TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment.
    2. The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19.
      Title: The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19.
    3. TAS2R agonists block signaling downstream of phosphatidylinositol 3-kinase
      Title: Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.
    4. Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes
      Title: Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.
    5. Intracellular signaling and cell mechanics using isolated human airway smooth muscle, mouse tracheal responses, and human bronchial responses to characterize TAS2R relaxation in the context of beta(2)AR desensitization.
      Title: TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.
    6. The formation of a short helical segment in intracellular loop II may be necessary for the activation of hTAS2R1.
      Title: Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies.
    7. Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).
      Title: Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).
    8. The ligand binding pocket in T2R1 is present on the extracellular surface of the receptor, and is formed by the transmembrane helices 1, 2, 3 and 7 and with extracellular loops 1 and 2 forming a cap like structure on the binding pocket.
      Title: Bitter taste receptor T2R1 is activated by dipeptides and tripeptides.
    9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A genome-wide linkage and association scan reveals novel loci for autism.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide linkage and association scan reveals novel loci for autism.
    EBI GWAS Catalog
    Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126778, MGC126780

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bitter taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bitter taste receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables taste receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    taste receptor type 2 member 1
    Names
    taste receptor, family B, member 7
    taste receptor, type 2, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386348.1 → NP_001373277.1  taste receptor type 2 member 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC026787, AC034214, AC091958
      UniProtKB/TrEMBL
      Q50L07
      Conserved Domains (1) summary
      cd15016
      Location:1 → 249
      7tm_TAS2R1; mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled receptor superfamily

    2. NM_019599.3 → NP_062545.1  taste receptor type 2 member 1 isoform 1

      See identical proteins and their annotated locations for NP_062545.1

      Status: REVIEWED

      Source sequence(s)
      AC034214
      Consensus CDS
      CCDS3876.1
      UniProtKB/Swiss-Prot
      Q646G8, Q9NYW7
      UniProtKB/TrEMBL
      Q502V6
      Related
      ENSP00000371932.2, ENST00000382492.4
      Conserved Domains (1) summary
      pfam05296
      Location:1 → 296
      TAS2R; Taste receptor protein (TAS2R)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      9627347..9903876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      9567134..9843682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NYW7.1 GenPept UniProtKB/Swiss-Prot:Q9NYW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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