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    ZNF451 zinc finger protein 451 [ Homo sapiens (human) ]

    Gene ID: 26036, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF451provided by HGNC
    Official Full Name
    zinc finger protein 451provided by HGNC
    Primary source
    HGNC:HGNC:21091
    See related
    Ensembl:ENSG00000112200 MIM:615708; AllianceGenome:HGNC:21091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZATT; COASTER; dJ417I1.1
    Summary
    Enables SUMO ligase activity; transcription corepressor activity; and transcription regulator inhibitor activity. Involved in negative regulation of transcription initiation by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in PML body. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 5.2) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF451 in Genome Data Viewer
    Location:
    6p12.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (57090188..57170305)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (56929190..57009330)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (56954986..57035103)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:56895065-56895565 Neighboring gene Sharpr-MPRA regulatory region 7771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56912079-56912956 Neighboring gene mitochondrial ribosomal protein L30 pseudogene 1 Neighboring gene KIAA1586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56954672-56955554 Neighboring gene ZNF451 regulatory antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:57037271-57038028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17304 Neighboring gene BAG cochaperone 2 Neighboring gene RAB23, member RAS oncogene family Neighboring gene DNA primase subunit 2 Neighboring gene long intergenic non-protein coding RNA 3001

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • FLJ23421, FLJ53246, FLJ90693, KIAA0576, KIAA1702, MGC26701

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables SUMO ligase activity  
    enables SUMO ligase activity PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    enables sequence-specific DNA binding  
    enables transcription corepressor activity  
    enables transcription corepressor activity PubMed 
    enables transcription regulator inhibitor activity PubMed 
    Component Evidence Code Pubs
    located_in PML body PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    E3 SUMO-protein ligase ZNF451
    Names
    E3 SUMO-protein transferase ZNF451
    coactivator for steroid receptors
    zinc finger protein associated with TDP2 and TOP2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031623.3 → NP_001026794.1  E3 SUMO-protein ligase ZNF451 isoform 1

      See identical proteins and their annotated locations for NP_001026794.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB011148, AK027805, AL136311, AY055204, CN314846
      Consensus CDS
      CCDS43477.1
      UniProtKB/Swiss-Prot
      Q5VVE9, Q5VVF1, Q86YE4, Q8N380, Q8TD15, Q9C0G1, Q9NQM1, Q9Y4E5
      UniProtKB/TrEMBL
      E9PH99
      Related
      ENSP00000359740.4, ENST00000370706.9
    2. NM_001257273.2 → NP_001244202.1  E3 SUMO-protein ligase ZNF451 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK302577, AL450489, CK301064
      Consensus CDS
      CCDS59026.1
      UniProtKB/TrEMBL
      B4DYS2
      Related
      ENSP00000359742.4, ENST00000370708.8
      Conserved Domains (1) summary
      pfam11560
      Location:358 → 498
      LAP2alpha; Lamina-associated polypeptide 2 alpha
    3. NM_015555.3 → NP_056370.2  E3 SUMO-protein ligase ZNF451 isoform 2

      See identical proteins and their annotated locations for NP_056370.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. Isoform 2 is shorter, compared to isoform 1.
      Source sequence(s)
      AA336048, AL136311, AY055204, BM559241, CN314846
      Consensus CDS
      CCDS4960.1
      UniProtKB/TrEMBL
      E9PH99
      Related
      ENSP00000350083.3, ENST00000357489.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      57090188..57170305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514460.3 → XP_011512762.1  E3 SUMO-protein ligase ZNF451 isoform X1

      UniProtKB/TrEMBL
      E9PH99
    2. XM_047418624.1 → XP_047274580.1  E3 SUMO-protein ligase ZNF451 isoform X3

      UniProtKB/TrEMBL
      E9PH99
    3. XM_011514462.4 → XP_011512764.1  E3 SUMO-protein ligase ZNF451 isoform X4

      UniProtKB/TrEMBL
      E9PH99
      Related
      ENST00000444273.6
    4. XM_011514463.3 → XP_011512765.1  E3 SUMO-protein ligase ZNF451 isoform X5

      Conserved Domains (1) summary
      pfam11560
      Location:330 → 470
      LAP2alpha; Lamina-associated polypeptide 2 alpha
    5. XM_011514461.3 → XP_011512763.1  E3 SUMO-protein ligase ZNF451 isoform X2

      UniProtKB/TrEMBL
      E9PH99

    RNA

    1. XR_007059234.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      56929190..57009330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355130.1 → XP_054211105.1  E3 SUMO-protein ligase ZNF451 isoform X1

      UniProtKB/TrEMBL
      E9PH99
    2. XM_054355132.1 → XP_054211107.1  E3 SUMO-protein ligase ZNF451 isoform X3

      UniProtKB/TrEMBL
      E9PH99
    3. XM_054355133.1 → XP_054211108.1  E3 SUMO-protein ligase ZNF451 isoform X4

      UniProtKB/TrEMBL
      E9PH99
    4. XM_054355134.1 → XP_054211109.1  E3 SUMO-protein ligase ZNF451 isoform X5

    5. XM_054355131.1 → XP_054211106.1  E3 SUMO-protein ligase ZNF451 isoform X2

      UniProtKB/TrEMBL
      E9PH99

    RNA

    1. XR_008487294.1 RNA Sequence

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