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    ACACA acetyl-CoA carboxylase alpha [ Homo sapiens (human) ]

    Gene ID: 31, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ACACAprovided by HGNC
    Official Full Name
    acetyl-CoA carboxylase alphaprovided by HGNC
    Primary source
    HGNC:HGNC:84
    See related
    Ensembl:ENSG00000278540 MIM:200350; AllianceGenome:HGNC:84
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACC; ACAC; ACC1; ACCA; Acac1; hACC1; ACACAD; ACCalpha; ACACalpha
    Summary
    Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 9.8), brain (RPKM 9.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ACACA in Genome Data Viewer
    Location:
    17q12
    Exon count:
    66
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (37084992..37406836, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38071975..38396996, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35441927..35766927, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene apoptosis antagonizing transcription factor Neighboring gene MPRA-validated peak2828 silencer Neighboring gene uncharacterized LOC105371753 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35405396-35405896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35421791-35422346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35422902-35423456 Neighboring gene microRNA 2909 Neighboring gene NANOG hESC enhancer GRCh37_chr17:35446662-35447163 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:35453499-35454698 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35460987-35461591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35464014-35464618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35464619-35465223 Neighboring gene NANOG hESC enhancer GRCh37_chr17:35499293-35499794 Neighboring gene high mobility group box 1 pseudogene 24 Neighboring gene ribosomal protein S2 pseudogene 49 Neighboring gene ribosomal protein L18a pseudogene 12 Neighboring gene small nucleolar RNA, H/ACA box 90 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35712269-35712768 Neighboring gene chromosome 17 open reading frame 78 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35768105-35768789 Neighboring gene transcriptional adaptor 2A Neighboring gene ribosomal protein L24 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr17:35814497-35815074 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:35815591-35816092 Neighboring gene MPRA-validated peak2830 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35843239-35843740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35851097-35851882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867118-35867618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867619-35868119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35872759-35873272 Neighboring gene dual specificity phosphatase 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Circular RNA circ‑ACACA regulates proliferation, migration and glycolysis in non‑small‑cell lung carcinoma via miR‑1183 and PI3K/PKB pathway. Wu W, et al. Int J Mol Med, 2020 Jun. PMID 32236577, Free PMC Article
    2. Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication. Spencer CM, et al. J Virol, 2011 Jun. PMID 21471234, Free PMC Article
    3. Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis. Scott KE, et al. PLoS One, 2012. PMID 22238651, Free PMC Article
    4. Structural Characterization of i-Motif Structure in the Human Acetyl-CoA Carboxylase 1 Gene Promoters and Their Role in the Regulation of Gene Expression. Kaulage MH, et al. Chembiochem, 2018 May 18. PMID 29485247
    5. Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Sinilnikova OM, et al. Cancer Epidemiol Biomarkers Prev, 2007 Mar. PMID 17372234

    See all (240) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA.
      Title: CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA.
    2. Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD.
      Title: Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD.
    3. Involvement of ACACA (acetyl-CoA carboxylase alpha) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts.
      Title: Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts.
    4. Identification of acetyl-CoA carboxylase alpha as a prognostic and targeted candidate for hepatocellular carcinoma.
      Title: Identification of acetyl-CoA carboxylase alpha as a prognostic and targeted candidate for hepatocellular carcinoma.
    5. Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-kappaB-snail axis.
      Title: Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-κB-snail axis.
    6. Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial beta-oxidation in castration-resistant prostate cancer cells.
      Title: Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial β-oxidation in castration-resistant prostate cancer cells.
    7. circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.
      Title: circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.
    8. [Research on the mechanism of hypoxia promoting the migration of lung adenocarcinoma A549 cells].
      Title: [Research on the mechanism of hypoxia promoting the migration of lung adenocarcinoma A549 cells].
    9. MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase.
      Title: MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase.
    10. ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
      Title: ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
    Submit: New GeneRIF Correction See all GeneRIFs (65)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Acetyl-CoA: carboxylase deficiency
    MedGen: C0268603 OMIM: 613933 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
    EBI GWAS Catalog
    GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Gag interacts with ACACA as demonstrated by proximity dependent biotinylation proteomics PubMed
    tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetyl-CoA carboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetyl-CoA carboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables acetyl-CoA carboxylase activity TAS
    Traceable Author Statement
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to prostaglandin E stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IC
    Inferred by Curator
    more info
    		  
    involved_in fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty-acyl-CoA biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in lipid homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in tissue homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    acetyl-CoA carboxylase 1
    Names
    ACC-alpha
    acetyl-Coenzyme A carboxylase alpha
    NP_942131.1
    NP_942133.1
    NP_942134.1
    NP_942135.1
    NP_942136.1
    XP_005257324.1
    XP_006721916.1
    XP_011523003.1
    XP_011523005.1
    XP_011523006.1
    XP_047291834.1
    XP_047291835.1
    XP_047291836.1
    XP_047291837.1
    XP_047291838.1
    XP_047291839.1
    XP_047291840.1
    XP_047291841.1
    XP_047291842.1
    XP_047291844.1
    XP_047291845.1
    XP_047291846.1
    XP_047291847.1
    XP_047291848.1
    XP_047291849.1
    XP_047291850.1
    XP_054171870.1
    XP_054171871.1
    XP_054171872.1
    XP_054171873.1
    XP_054171874.1
    XP_054171875.1
    XP_054171876.1
    XP_054171877.1
    XP_054171878.1
    XP_054171879.1
    XP_054171880.1
    XP_054171881.1
    XP_054171882.1
    XP_054171883.1
    XP_054171884.1
    XP_054171885.1
    XP_054171886.1
    XP_054171887.1
    XP_054185260.1
    XP_054185261.1
    XP_054185262.1
    XP_054185263.1
    XP_054185264.1
    XP_054185265.1
    XP_054185266.1
    XP_054185267.1
    XP_054185268.1
    XP_054185269.1
    XP_054185270.1
    XP_054185271.1
    XP_054185272.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023295.2 RefSeqGene

      Range
      4976..326820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_198834.3 → NP_942131.1  acetyl-CoA carboxylase 1 isoform 1

      See identical proteins and their annotated locations for NP_942131.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB371587, AC243654, AY315625, BC041598, CF454424
      Consensus CDS
      CCDS42302.1
      UniProtKB/TrEMBL
      A2NX49
      Related
      ENSP00000483300.1, ENST00000616317.5
      Conserved Domains (8) summary
      COG0439
      Location:155 → 657
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:708 → 855
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:155 → 274
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:790 → 855
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1706 → 2254
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:544 → 651
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:857 → 1606
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:316 → 507
      ATP-grasp_4; ATP-grasp domain

    2. NM_198836.3 → NP_942133.1  acetyl-CoA carboxylase 1 isoform 2

      See identical proteins and their annotated locations for NP_942133.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR exon, and uses a downstream start codon, as compared to variant (1). The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AB371587, AY315621, BC041598
      Consensus CDS
      CCDS11317.1
      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49
      Related
      ENSP00000478547.1, ENST00000614428.4
      Conserved Domains (5) summary
      COG0439
      Location:118 → 620
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:671 → 818
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:754 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1669 → 2217
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1569
      ACC_central; Acetyl-CoA carboxylase, central region

    3. NM_198837.2 → NP_942134.1  acetyl-CoA carboxylase 1 isoform 3

      See identical proteins and their annotated locations for NP_942134.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has a shorter and alternate 5' sequence, as compared to variant 1. The resulting isoform (3) has a distinct and shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AY315620, AY315627, BC031485, BC041598, U19822
      Consensus CDS
      CCDS11318.1
      UniProtKB/TrEMBL
      A2NX49
      Related
      ENSP00000482269.1, ENST00000612895.4
      Conserved Domains (8) summary
      COG0439
      Location:60 → 562
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:613 → 760
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:60 → 179
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:695 → 760
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1611 → 2159
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:449 → 556
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:762 → 1511
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:221 → 412
      ATP-grasp_4; ATP-grasp domain

    4. NM_198838.2 → NP_942135.1  acetyl-CoA carboxylase 1 isoform 4

      See identical proteins and their annotated locations for NP_942135.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has a shorter and alternate 5' sequence and uses a downstream start codon, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AY315619, AY315627, BC031485, BC041598, U19822
      Consensus CDS
      CCDS42303.1
      UniProtKB/TrEMBL
      A2NX49
      Related
      ENSP00000482368.1, ENST00000617649.4
      Conserved Domains (8) summary
      COG0439
      Location:40 → 542
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:593 → 740
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:40 → 159
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:675 → 740
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1591 → 2139
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:429 → 536
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:742 → 1491
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:201 → 392
      ATP-grasp_4; ATP-grasp domain

    5. NM_198839.3 → NP_942136.1  acetyl-CoA carboxylase 1 isoform 2

      See identical proteins and their annotated locations for NP_942136.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is the longest transcript, which has several additional exons in the 5' region, as compared to variant 1. It uses a downstream start codon and the resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AB371587, AC243654, AY315623, BC041598, CF454424
      Consensus CDS
      CCDS11317.1
      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49
      Conserved Domains (5) summary
      COG0439
      Location:118 → 620
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:671 → 818
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:754 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1669 → 2217
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1569
      ACC_central; Acetyl-CoA carboxylase, central region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      37084992..37406836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524701.2 → XP_011523003.1  acetyl-CoA carboxylase 1 isoform X2

      See identical proteins and their annotated locations for XP_011523003.1

      UniProtKB/TrEMBL
      A2NX49
      Conserved Domains (8) summary
      COG0439
      Location:125 → 627
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:678 → 825
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:125 → 244
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:760 → 825
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1676 → 2224
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:514 → 621
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:827 → 1576
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:286 → 477
      ATP-grasp_4; ATP-grasp domain

    2. XM_006721853.2 → XP_006721916.1  acetyl-CoA carboxylase 1 isoform X1

      UniProtKB/TrEMBL
      A2NX49
      Conserved Domains (8) summary
      COG0439
      Location:155 → 657
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:708 → 855
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:155 → 274
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:790 → 855
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1698 → 2246
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:544 → 651
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:857 → 1598
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:316 → 507
      ATP-grasp_4; ATP-grasp domain

    3. XM_047435882.1 → XP_047291838.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49

    4. XM_047435883.1 → XP_047291839.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49

    5. XM_047435881.1 → XP_047291837.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49

    6. XM_047435879.1 → XP_047291835.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49

    7. XM_047435880.1 → XP_047291836.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49

    8. XM_047435878.1 → XP_047291834.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49

    9. XM_047435892.1 → XP_047291848.1  acetyl-CoA carboxylase 1 isoform X7

      UniProtKB/TrEMBL
      A2NX49

    10. XM_005257267.6 → XP_005257324.1  acetyl-CoA carboxylase 1 isoform X6

      See identical proteins and their annotated locations for XP_005257324.1

      UniProtKB/TrEMBL
      A2NX49
      Conserved Domains (8) summary
      COG0439
      Location:40 → 542
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:593 → 740
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:40 → 159
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:675 → 740
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1591 → 2139
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:429 → 536
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:742 → 1491
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:201 → 392
      ATP-grasp_4; ATP-grasp domain

    11. XM_047435891.1 → XP_047291847.1  acetyl-CoA carboxylase 1 isoform X7

      UniProtKB/TrEMBL
      A2NX49

    12. XM_011524704.3 → XP_011523006.1  acetyl-CoA carboxylase 1 isoform X6

      See identical proteins and their annotated locations for XP_011523006.1

      UniProtKB/TrEMBL
      A2NX49
      Conserved Domains (8) summary
      COG0439
      Location:40 → 542
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:593 → 740
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:40 → 159
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:675 → 740
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1591 → 2139
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:429 → 536
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:742 → 1491
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:201 → 392
      ATP-grasp_4; ATP-grasp domain

    13. XM_047435884.1 → XP_047291840.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/TrEMBL
      A2NX49

    14. XM_047435893.1 → XP_047291849.1  acetyl-CoA carboxylase 1 isoform X7

      UniProtKB/TrEMBL
      A2NX49

    15. XM_047435890.1 → XP_047291846.1  acetyl-CoA carboxylase 1 isoform X6

      UniProtKB/TrEMBL
      A2NX49

    16. XM_047435885.1 → XP_047291841.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/TrEMBL
      A2NX49

    17. XM_011524703.1 → XP_011523005.1  acetyl-CoA carboxylase 1 isoform X3

      See identical proteins and their annotated locations for XP_011523005.1

      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49
      Conserved Domains (5) summary
      COG0439
      Location:118 → 620
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:671 → 818
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:754 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1669 → 2217
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1569
      ACC_central; Acetyl-CoA carboxylase, central region

    18. XM_047435888.1 → XP_047291844.1  acetyl-CoA carboxylase 1 isoform X5

      UniProtKB/TrEMBL
      A2NX49

    19. XM_047435886.1 → XP_047291842.1  acetyl-CoA carboxylase 1 isoform X8

      UniProtKB/TrEMBL
      A2NX49

    20. XM_047435889.1 → XP_047291845.1  acetyl-CoA carboxylase 1 isoform X5

      UniProtKB/TrEMBL
      A2NX49

    21. XM_047435894.1 → XP_047291850.1  acetyl-CoA carboxylase 1 isoform X9

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1320992..1645992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329294.1 → XP_054185269.1  acetyl-CoA carboxylase 1 isoform X6

      UniProtKB/TrEMBL
      A2NX49

    2. XM_054329286.1 → XP_054185261.1  acetyl-CoA carboxylase 1 isoform X2

      UniProtKB/TrEMBL
      A2NX49

    3. XM_054329285.1 → XP_054185260.1  acetyl-CoA carboxylase 1 isoform X1

      UniProtKB/TrEMBL
      A2NX49

    4. XM_054329287.1 → XP_054185262.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49

    5. XM_054329296.1 → XP_054185271.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49

    6. XM_054329288.1 → XP_054185263.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/TrEMBL
      A2NX49

    7. XM_054329295.1 → XP_054185270.1  acetyl-CoA carboxylase 1 isoform X7

      UniProtKB/TrEMBL
      A2NX49

    8. XM_054329292.1 → XP_054185267.1  acetyl-CoA carboxylase 1 isoform X6

      UniProtKB/TrEMBL
      A2NX49

    9. XM_054329293.1 → XP_054185268.1  acetyl-CoA carboxylase 1 isoform X6

      UniProtKB/TrEMBL
      A2NX49

    10. XM_054329289.1 → XP_054185264.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/TrEMBL
      A2NX49

    11. XM_054329291.1 → XP_054185266.1  acetyl-CoA carboxylase 1 isoform X5

      UniProtKB/TrEMBL
      A2NX49

    12. XM_054329290.1 → XP_054185265.1  acetyl-CoA carboxylase 1 isoform X5

      UniProtKB/TrEMBL
      A2NX49

    13. XM_054329297.1 → XP_054185272.1  acetyl-CoA carboxylase 1 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      38071975..38396996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315907.1 → XP_054171882.1  acetyl-CoA carboxylase 1 isoform X6

      UniProtKB/TrEMBL
      A2NX49

    2. XM_054315898.1 → XP_054171873.1  acetyl-CoA carboxylase 1 isoform X2

      UniProtKB/TrEMBL
      A2NX49

    3. XM_054315897.1 → XP_054171872.1  acetyl-CoA carboxylase 1 isoform X1

      UniProtKB/TrEMBL
      A2NX49

    4. XM_054315896.1 → XP_054171871.1  acetyl-CoA carboxylase 1 isoform X12

      UniProtKB/TrEMBL
      A2NX49

    5. XM_054315895.1 → XP_054171870.1  acetyl-CoA carboxylase 1 isoform X11

      UniProtKB/TrEMBL
      A2NX49

    6. XM_054315899.1 → XP_054171874.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49

    7. XM_054315911.1 → XP_054171886.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RP68, B2ZZ90, Q13085, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
      UniProtKB/TrEMBL
      A2NX49

    8. XM_054315901.1 → XP_054171876.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/TrEMBL
      A2NX49

    9. XM_054315910.1 → XP_054171885.1  acetyl-CoA carboxylase 1 isoform X7

      UniProtKB/TrEMBL
      A2NX49

    10. XM_054315908.1 → XP_054171883.1  acetyl-CoA carboxylase 1 isoform X7

      UniProtKB/TrEMBL
      A2NX49

    11. XM_054315904.1 → XP_054171879.1  acetyl-CoA carboxylase 1 isoform X6

      UniProtKB/TrEMBL
      A2NX49

    12. XM_054315909.1 → XP_054171884.1  acetyl-CoA carboxylase 1 isoform X7

      UniProtKB/TrEMBL
      A2NX49

    13. XM_054315905.1 → XP_054171880.1  acetyl-CoA carboxylase 1 isoform X6

      UniProtKB/TrEMBL
      A2NX49

    14. XM_054315900.1 → XP_054171875.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/TrEMBL
      A2NX49

    15. XM_054315906.1 → XP_054171881.1  acetyl-CoA carboxylase 1 isoform X6

      UniProtKB/TrEMBL
      A2NX49

    16. XM_054315903.1 → XP_054171878.1  acetyl-CoA carboxylase 1 isoform X5

      UniProtKB/TrEMBL
      A2NX49

    17. XM_054315902.1 → XP_054171877.1  acetyl-CoA carboxylase 1 isoform X5

      UniProtKB/TrEMBL
      A2NX49

    18. XM_054315912.1 → XP_054171887.1  acetyl-CoA carboxylase 1 isoform X13

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_000664.3: Suppressed sequence

      Description
      NM_000664.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_198835.1: Suppressed sequence

      Description
      NM_198835.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13085.2 GenPept UniProtKB/Swiss-Prot:Q13085

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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