Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Pr55(Gag)
|
gag
|
HIV-1 Gag co-localizes with eIF-2alpha in human cells |
PubMed
|
Tat
|
tat
|
Exposure of human umbilical vein endothelial cells to HIV-1 Tat causes broad activation of the unfolded-protein response in ER with phosphorylation of PERK, eIF2alpha, and JNK and induction of Grp78/BiP |
PubMed
|
|
tat
|
Neurons exposed to HIV-1 Tat induces calcium loss from the endoplasmic reticulum via ryanodine receptor (RyR) and increases the phosphorylated levels of PERK, eIF2a, and XBP1 |
PubMed
|
|
tat
|
HIV-1 Tat competes with eukaryotic initiation factor 2, a well characterized substrate of PKR, for phosphorylation by activated PKR |
PubMed
|
|
tat
|
Eukaryotic translation initiation factor 2 (eIF2) recognizes and binds the TAR secondary structure in HIV-1 RNA, suggesting a role in Tat transactivation of the viral LTR promoter |
PubMed
|
Go to the HIV-1, Human Interaction Database