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    TLR8-AS1 TLR8 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 349408, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TLR8-AS1provided by HGNC
    Official Full Name
    TLR8 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:40720
    See related
    Ensembl:ENSG00000233338 AllianceGenome:HGNC:40720
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GS1-324M7.6
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See TLR8-AS1 in Genome Data Viewer
    Location:
    Xp22.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (12902817..12943300, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (12484286..12524764, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (12920936..12961419, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L35 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29414 Neighboring gene toll like receptor 7 Neighboring gene Sharpr-MPRA regulatory region 5588 Neighboring gene toll like receptor 8 Neighboring gene CRISPRi-validated cis-regulatory element chrX.229 Neighboring gene Sharpr-MPRA regulatory region 4636 Neighboring gene CRISPRi-validated cis-regulatory element chrX.231 Neighboring gene CRISPRi-validated cis-regulatory element chrX.232 Neighboring gene CRISPRi-validated cis-regulatory element chrX.233 Neighboring gene CRISPRi-validated cis-regulatory element chrX.234 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:12982027-12982688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29422 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:12992269-12993108 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:12993948-12994786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29423 Neighboring gene CRISPRi-validated cis-regulatory element chrX.239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29424 Neighboring gene CRISPRi-validated cis-regulatory element chrX.240 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:13005300-13005496 Neighboring gene thymosin beta 4 X-linked Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29430 Neighboring gene family with sequence similarity 9 member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA TLR8-AS1 promotes metastasis and chemoresistance of ovarian cancer through enhancing TLR8 mRNA stability. Xu Q, et al. Biochem Biophys Res Commun, 2020 Jun 11. PMID 32278547
    2. Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis. Peng C, et al. J Hypertens, 2023 Aug 1. PMID 37199563
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis.
      Title: Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis.
    2. LncRNA TLR8-AS1 promotes metastasis and chemoresistance of ovarian cancer through enhancing TLR8 mRNA stability.
      Title: LncRNA TLR8-AS1 promotes metastasis and chemoresistance of ovarian cancer through enhancing TLR8 mRNA stability.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • TLR8 antisense RNA 1 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_030727.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139705, BC037548
      Related
      ENST00000451564.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      12902817..12943300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      12484286..12524764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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