Pclaf PCNA clamp associated factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pclafprovided by MGI
Official Full Name: PCNA clamp associated factorprovided by MGI
Primary source: MGI:MGI:1915276
See related: Ensembl:ENSMUSG00000040204 AllianceGenome:MGI:1915276
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Paf; PAF15; Ns5apt9; Ns5atp9; p15(PAF); mKIAA0101; 2810417H13Rik
Summary: Predicted to enable chromatin binding activity and molecular adaptor activity. Predicted to be involved in several processes, including DNA metabolic process; centrosome cycle; and response to UV. Predicted to be located in centrosome and perinuclear region of cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; facial prominence; limb; and skin. Orthologous to human PCLAF (PCNA clamp associated factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E14 (RPKM 37.6), CNS E11.5 (RPKM 37.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 35.58 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (65797605..65810833)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (65890323..65903551)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UHRF1 ubiquitinates PAF15 at Lys 15 and Lys 24 and promotes its binding to PCNA during late S-phase
Title: Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells.
Results unveil an unsuspected role of the PAF-Wnt signalling axis in modulating cell plasticity, which is required for the maintenance of breast cancer cell stemness.
Title: PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness.
PAF-induced ductal epithelial cell hyperproliferation was accompanied by extracellular signal-regulated kinase (ERK) phosphorylation independently of Ras or Raf mutations.
Title: PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis.
Paf as a novel and essential regulator of early hematopoiesis.
Title: The Paf oncogene is essential for hematopoietic stem cell function and development.
highly restricted expression of the p15(PAF) gene in a spatio-temporal manner during embryogenesis
Title: Murine embryonic expression of the gene for the UV-responsive protein p15(PAF).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125860 (e-PCR)
- UniSTS:162597

NoName (e-PCR)
- UniSTS:236168

NoName (e-PCR)
- UniSTS:236169

BB191711 (e-PCR)
- UniSTS:185792

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in translesion synthesis	ISO Inferred from Sequence Orthology more info
involved_in translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: PCNA-associated factor

Names: HCV NS5A-transactivated protein 9 homolog; PCNA-associated factor of 15 kDa; p15PAF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.