Fbxo44 F-box protein 44 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxo44provided by MGI
Official Full Name: F-box protein 44provided by MGI
Primary source: MGI:MGI:1354744
See related: Ensembl:ENSMUSG00000029001 AllianceGenome:MGI:1354744
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FBG3; FBX30; Fbx6a; Fbxo6a; 5730411K09
Summary: Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to act upstream of or within proteasomal protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in brain; gut; and male reproductive gland or organ. Orthologous to human FBXO44 (F-box protein 44). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 49.7), cerebellum adult (RPKM 30.0) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 78.67 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148237256..148244663, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148152799..148160183, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex.
Title: FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F-box only protein 44

Names: F-box only protein 6a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161851.2 → NP_001155323.1 F-box only protein 44 isoform 1

See identical proteins and their annotated locations for NP_001155323.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode isoform 1.

Source sequence(s)

AK077452, BP761336, BQ042735, BY292524

Consensus CDS

CCDS18934.1

UniProtKB/Swiss-Prot

Q8BK26, Q8K128

UniProtKB/TrEMBL

A2A7H5

Related

ENSMUSP00000126551.2, ENSMUST00000167160.8

Conserved Domains (2) summary

pfam04300
Location:72 → 248

FBA; F-box associated region

pfam12937
Location:6 → 51

F-box-like
NM_001161852.2 → NP_001155324.1 F-box only protein 44 isoform 2

See identical proteins and their annotated locations for NP_001155324.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site and lacks an internal exon, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus and lacks an F-box-associated domain, compared to isoform 1.

Source sequence(s)

AK077452, BM932876, BP761336, BQ042735, BY128919, BY252242

Consensus CDS

CCDS51377.1

UniProtKB/TrEMBL

A2A7H6

Related

ENSMUSP00000101330.3, ENSMUST00000105705.9

Conserved Domains (2) summary

pfam04300
Location:72 → 122

FBA; F-box associated region

pfam12937
Location:6 → 51

F-box-like
NM_001355701.1 → NP_001342630.1 F-box only protein 44 isoform 3

Status: VALIDATED

Source sequence(s)

AL606929, BM932876, BQ042735, BY128919, BY252242

UniProtKB/TrEMBL

E9PUJ0

Conserved Domains (2) summary

pfam04300
Location:72 → 208

FBA; F-box associated region

pfam12937
Location:6 → 51

F-box-like; F-box-like
NM_001355702.1 → NP_001342631.1 F-box only protein 44 isoform 4

Status: VALIDATED

Source sequence(s)

AL606929, BM932876, BQ042735, BY128919, BY252242

UniProtKB/TrEMBL

F6UI76

Conserved Domains (1) summary

pfam04300
Location:13 → 132

FBA; F-box associated region
NM_173401.5 → NP_775577.2 F-box only protein 44 isoform 1

See identical proteins and their annotated locations for NP_775577.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform.

Source sequence(s)

AK077452, BP761336, BQ042735, BY128919, BY252242

Consensus CDS

CCDS18934.1

UniProtKB/Swiss-Prot

Q8BK26, Q8K128

UniProtKB/TrEMBL

A2A7H5

Related

ENSMUSP00000054022.3, ENSMUST00000057907.10

Conserved Domains (2) summary

pfam04300
Location:72 → 248

FBA; F-box associated region

pfam12937
Location:6 → 51

F-box-like

RNA

NR_104374.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) includes an alternate 5' terminal exon and an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK077452, AL606929, BP761336, BY252242, CX202860

Related

ENSMUST00000129253.8
NR_104375.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks a 5' exon and includes an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK077452, BP761336, BY252242, CX202860

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

148237256..148244663 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253501.2 → XP_030109361.1 F-box only protein 44 isoform X2

UniProtKB/TrEMBL

A2A7H6

Conserved Domains (2) summary

pfam04300
Location:72 → 122

FBA; F-box associated region

pfam12937
Location:6 → 51

F-box-like
XM_017320176.2 → XP_017175665.1 F-box only protein 44 isoform X1

UniProtKB/Swiss-Prot

Q8BK26, Q8K128

UniProtKB/TrEMBL

A2A7H5

Conserved Domains (2) summary

pfam04300
Location:72 → 248

FBA; F-box associated region

pfam12937
Location:6 → 51

F-box-like
XM_030253508.1 → XP_030109368.1 F-box only protein 44 isoform X3

Conserved Domains (1) summary

pfam04300
Location:13 → 172

FBA; F-box associated region
XM_030253504.2 → XP_030109364.1 F-box only protein 44 isoform X3

Conserved Domains (1) summary

pfam04300
Location:13 → 172

FBA; F-box associated region
XM_017320180.3 → XP_017175669.1 F-box only protein 44 isoform X4

Conserved Domains (1) summary

pfam04300
Location:13 → 46

FBA; F-box associated region
XM_030253500.2 → XP_030109360.1 F-box only protein 44 isoform X2

UniProtKB/TrEMBL

A2A7H6

Conserved Domains (2) summary

pfam04300
Location:72 → 122

FBA; F-box associated region

pfam12937
Location:6 → 51

F-box-like
XM_030253507.2 → XP_030109367.1 F-box only protein 44 isoform X3

Conserved Domains (1) summary

pfam04300
Location:13 → 172

FBA; F-box associated region
XM_030253506.2 → XP_030109366.1 F-box only protein 44 isoform X3

Conserved Domains (1) summary

pfam04300
Location:13 → 172

FBA; F-box associated region
XM_030253505.2 → XP_030109365.1 F-box only protein 44 isoform X3

Conserved Domains (1) summary

pfam04300
Location:13 → 172

FBA; F-box associated region
XM_017320178.3 → XP_017175667.1 F-box only protein 44 isoform X1

UniProtKB/Swiss-Prot

Q8BK26, Q8K128

UniProtKB/TrEMBL

A2A7H5

Conserved Domains (2) summary

pfam04300
Location:72 → 248

FBA; F-box associated region

pfam12937
Location:6 → 51

F-box-like
XM_030253503.2 → XP_030109363.1 F-box only protein 44 isoform X2

UniProtKB/TrEMBL

A2A7H6

Conserved Domains (2) summary

pfam04300
Location:72 → 122

FBA; F-box associated region

pfam12937
Location:6 → 51

F-box-like
XM_030253502.2 → XP_030109362.1 F-box only protein 44 isoform X2

UniProtKB/TrEMBL

A2A7H6

Conserved Domains (2) summary

pfam04300
Location:72 → 122

FBA; F-box associated region

pfam12937
Location:6 → 51

F-box-like
XM_017320177.2 → XP_017175666.1 F-box only protein 44 isoform X1

UniProtKB/Swiss-Prot

Q8BK26, Q8K128

UniProtKB/TrEMBL

A2A7H5

Conserved Domains (2) summary

pfam04300
Location:72 → 248

FBA; F-box associated region

pfam12937
Location:6 → 51

F-box-like