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    Gm572 predicted gene 572 [ Mus musculus (house mouse) ]

    Gene ID: 230909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gm572provided by MGI
    Official Full Name
    predicted gene 572provided by MGI
    Primary source
    MGI:MGI:2685418
    See related
    Ensembl:ENSMUSG00000070577 AllianceGenome:MGI:2685418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b2b1167Clo
    Summary
    Acts upstream of or within determination of left/right symmetry and heart development. Is expressed in several structures, including alimentary system; genitourinary system; and trachea. Used to study Kartagener syndrome; primary ciliary dyskinesia; and visceral heterotaxy. Orthologous to human C1orf127 (chromosome 1 open reading frame 127). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 5.0), heart adult (RPKM 5.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gm572 in Genome Data Viewer
    Location:
    4 E2; 4 78.82 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148727774..148761562)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148643317..148677105)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene MBL associated serine protease 2 Neighboring gene spermidine synthase Neighboring gene TAR DNA binding protein Neighboring gene STARR-positive B cell enhancer ABC_E4729 Neighboring gene STARR-seq mESC enhancer starr_12080 Neighboring gene STARR-seq mESC enhancer starr_12082 Neighboring gene STARR-seq mESC enhancer starr_12083 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:148057732-148057915 Neighboring gene predicted gene 13203 Neighboring gene STARR-seq mESC enhancer starr_12087 Neighboring gene STARR-seq mESC enhancer starr_12089 Neighboring gene predicted gene, 32897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. Timmermans S, et al. JCI Insight, 2018 Jul 12. PMID 29997285, Free PMC Article
    2. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
    3. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Targeted (4) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein C1orf127 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085505.1 → NP_001078974.1  uncharacterized protein C1orf127 homolog isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL606969
      Consensus CDS
      CCDS51378.1
      UniProtKB/TrEMBL
      B1ARY8
      Related
      ENSMUSP00000101323.3, ENSMUST00000105698.3
      Conserved Domains (1) summary
      pfam15094
      Location:144 → 358
      DUF4556; Domain of unknown function (DUF4556)

    2. NM_001368835.1 → NP_001355764.1  uncharacterized protein C1orf127 homolog isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL606969
      Related
      ENSMUSP00000160098.1, ENSMUST00000250014.1
      Conserved Domains (2) summary
      PHA03247
      Location:370 → 767
      PHA03247; large tegument protein UL36; Provisional
      pfam15094
      Location:144 → 358
      DUF4556; Domain of unknown function (DUF4556)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148727774..148761562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164087.1 → XP_036019980.1  uncharacterized protein C1orf127 homolog isoform X3

      Conserved Domains (1) summary
      pfam15094
      Location:144 → 358
      DUF4556; Domain of unknown function (DUF4556)

    2. XM_036164088.1 → XP_036019981.1  uncharacterized protein C1orf127 homolog isoform X4

      Conserved Domains (1) summary
      pfam15094
      Location:144 → 358
      DUF4556; Domain of unknown function (DUF4556)

    3. XM_006538816.3 → XP_006538879.1  uncharacterized protein C1orf127 homolog isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:324 → 721
      PHA03247; large tegument protein UL36; Provisional
      pfam15094
      Location:144 → 312
      DUF4556; Domain of unknown function (DUF4556)

    4. XM_006538818.2 → XP_006538881.1  uncharacterized protein C1orf127 homolog isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:150 → 475
      PHA03247; large tegument protein UL36; Provisional
      pfam15094
      Location:2 → 138
      DUF4556; Domain of unknown function (DUF4556)
    Nucleotide Protein Strain
    Heading Accession and Version

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