Spinkl serine protease inhibitor, Kazal type-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spinklprovided by MGI
Official Full Name: serine protease inhibitor, Kazal type-likeprovided by MGI
Primary source: MGI:MGI:1924674
See related: Ensembl:ENSMUSG00000053729 AllianceGenome:MGI:1924674
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9530002K18Rik
Summary: Acts upstream of or within negative regulation of sperm capacitation and positive regulation of flagellated sperm motility. Located in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 18 B3; 18 23.74 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (44299425..44309774, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (44166358..44176707, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPINKL's binding to ejaculated sperm in the uterus but not in the oviduct suggest that SPINKL serves as a sperm protector in the uterus by preventing premature capacitation.
Title: Mechanisms underlying the inhibition of murine sperm capacitation by the seminal protein, SPINKL.

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General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of sperm capacitation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine protease inhibitor kazal-like protein, minor form

Names: SPINKL, minor form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183123.2 → NP_898946.1 serine protease inhibitor kazal-like protein, minor form precursor

See identical proteins and their annotated locations for NP_898946.1

Status: VALIDATED

Source sequence(s)

AK020535

Consensus CDS

CCDS50273.1

UniProtKB/Swiss-Prot

Q8CEK3

Related

ENSMUSP00000063376.4, ENSMUST00000066328.5

Conserved Domains (1) summary

cd00104
Location:48 → 74

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

44299425..44309774 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526352.4 → XP_006526415.1 serine protease inhibitor kazal-like protein, minor form isoform X1

See identical proteins and their annotated locations for XP_006526415.1

UniProtKB/Swiss-Prot

Q8CEK3

Conserved Domains (1) summary

cd00104
Location:48 → 74

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...