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    Mrps36 mitochondrial ribosomal protein S36 [ Mus musculus (house mouse) ]

    Gene ID: 66128, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrps36provided by MGI
    Official Full Name
    mitochondrial ribosomal protein S36provided by MGI
    Primary source
    MGI:MGI:1913378
    See related
    Ensembl:ENSMUSG00000061474 AllianceGenome:MGI:1913378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kgd4; S36mt; 1110018B13Rik
    Summary
    Enables protein-macromolecule adaptor activity. Involved in 2-oxoglutarate metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Part of oxoglutarate dehydrogenase complex. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human KGD4 (alpha-ketoglutarate dehydrogenase subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 42.2), testis adult (RPKM 40.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrps36 in Genome Data Viewer
    Location:
    13 D1; 13 53.23 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100872448..100881167, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100735940..100744659, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6 Neighboring gene STARR-seq mESC enhancer starr_35476 Neighboring gene coiled-coil domain containing 125 Neighboring gene cyclin dependent kinase 7 Neighboring gene STARR-seq mESC enhancer starr_35477 Neighboring gene STARR-positive B cell enhancer ABC_E7269 Neighboring gene STARR-positive B cell enhancer mm9_chr13:101513935-101514236 Neighboring gene centromere protein H Neighboring gene STARR-positive B cell enhancer ABC_E1886 Neighboring gene cyclin B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex. Hevler JF, et al. Open Biol, 2023 Mar. PMID 36854377, Free PMC Article
    2. The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase. Heublein M, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165143, Free PMC Article
    3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    4. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 2-oxoglutarate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oxoglutarate dehydrogenase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-ketoglutarate dehydrogenase component 4
    Names
    28S ribosomal protein S36, mitochondrial
    alpha-ketoglutarate dehydrogenase subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190264.1 → NP_001177193.1  alpha-ketoglutarate dehydrogenase component 4 isoform 2

      See identical proteins and their annotated locations for NP_001177193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC165159, AK009966
      Consensus CDS
      CCDS49347.1
      UniProtKB/TrEMBL
      Q9D6T9
      Related
      ENSMUSP00000104954.2, ENSMUST00000078573.5

    2. NM_025369.3 → NP_079645.1  alpha-ketoglutarate dehydrogenase component 4 isoform 1

      See identical proteins and their annotated locations for NP_079645.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC165159, AK003765
      Consensus CDS
      CCDS36767.1
      UniProtKB/Swiss-Prot
      Q4VA25, Q9CQX8
      Related
      ENSMUSP00000104957.2, ENSMUST00000109333.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      100872448..100881167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQX8.1 GenPept UniProtKB/Swiss-Prot:Q9CQX8

    Gene LinkOut

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