Pdcl2 phosducin-like 2 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Pdcl2provided by MGI
Official Full Name: phosducin-like 2provided by MGI
Primary source: MGI:MGI:1890655
See related: Ensembl:ENSMUSG00000029235 AllianceGenome:MGI:1890655
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tphlp; Mgcphlp; 1700010B22Rik; 1700016K07Rik
Summary: Acts upstream of or within acrosome assembly and sperm axoneme assembly. Is active in endoplasmic reticulum. Orthologous to human PDCL2 (phosducin like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 38.1) See more
Orthologs: human all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (76459963..76479003, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (76312116..76331156, complement)

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDCL2 is essential for sperm acrosome formation and male fertility in mice.
Title: PDCL2 is essential for sperm acrosome formation and male fertility in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acrosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acrosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sperm flagellum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosducin-like protein 2

Names: phosducin-like protein similar 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310637.1 → NP_001297566.1 phosducin-like protein 2 isoform 2

See identical proteins and their annotated locations for NP_001297566.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AK132738, AK133140

Consensus CDS

CCDS80304.1

UniProtKB/Swiss-Prot

Q78Y63

Related

ENSMUSP00000113699.2, ENSMUST00000122213.8

Conserved Domains (1) summary

cd02988
Location:19 → 152

Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...
NM_023508.7 → NP_075997.1 phosducin-like protein 2 isoform 1

See identical proteins and their annotated locations for NP_075997.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK005814, AK132738, AK133140

Consensus CDS

CCDS39116.1

UniProtKB/Swiss-Prot

Q3V0H7, Q78Y63, Q9DA99, Q9WUP3

Related

ENSMUSP00000031145.7, ENSMUST00000031145.7

Conserved Domains (1) summary

cd02988
Location:8 → 200

Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...