Cwf19l1 CWF19 like cell cycle control factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cwf19l1provided by MGI
Official Full Name: CWF19 like cell cycle control factor 1provided by MGI
Primary source: MGI:MGI:1919752
See related: Ensembl:ENSMUSG00000025200 AllianceGenome:MGI:1919752
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable RNA lariat debranching enzyme activator activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 17. Orthologous to human CWF19L1 (CWF19 like cell cycle control factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E14 (RPKM 3.0), CNS E18 (RPKM 3.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 36.72 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (44097076..44124324, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (44108637..44135876, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA571393 (e-PCR)
- UniSTS:209469

AI854304 (e-PCR)
- UniSTS:181243

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA lariat debranching enzyme activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of post-mRNA release spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CWF19-like protein 1

Names: CWF19-like 1, cell cycle control

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081077.1 → NP_001074546.1 CWF19-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_001074546.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1)

Source sequence(s)

AC125101

Consensus CDS

CCDS37995.1

UniProtKB/Swiss-Prot

E9QNL3, Q05CB7, Q3UT85, Q8C2J2, Q8CI33

Related

ENSMUSP00000026218.6, ENSMUST00000026218.7

Conserved Domains (3) summary

cd07380
Location:9 → 229

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:446 → 534

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:327 → 422

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
NM_001356578.1 → NP_001343507.1 CWF19-like protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' structure, resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC125101

Conserved Domains (3) summary

cd07380
Location:9 → 91

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:304 → 396

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:189 → 284

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

44097076..44124324 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527364.3 → XP_006527427.1 CWF19-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006527427.1

UniProtKB/Swiss-Prot

Q8CI33

Conserved Domains (3) summary

cd07380
Location:9 → 91

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:304 → 396

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:189 → 284

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_030251084.1 → XP_030106944.1 CWF19-like protein 1 isoform X2

Conserved Domains (2) summary

pfam04676
Location:197 → 289

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:82 → 177

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_036161696.1 → XP_036017589.1 CWF19-like protein 1 isoform X2

Conserved Domains (2) summary

pfam04676
Location:197 → 289

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:82 → 177

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_011247358.3 → XP_011245660.1 CWF19-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_011245660.1

UniProtKB/Swiss-Prot

Q8CI33

Conserved Domains (3) summary

cd07380
Location:9 → 91

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:304 → 396

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:189 → 284

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_030251083.2 → XP_030106943.1 CWF19-like protein 1 isoform X1

Conserved Domains (3) summary

cd07380
Location:9 → 91

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:304 → 396

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:189 → 284

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_017318296.2 → XP_017173785.1 CWF19-like protein 1 isoform X1

UniProtKB/Swiss-Prot

Q8CI33

Related

ENSMUST00000237067.2

Conserved Domains (3) summary

cd07380
Location:9 → 91

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:304 → 396

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:189 → 284

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_036161695.1 → XP_036017588.1 CWF19-like protein 1 isoform X1

Conserved Domains (3) summary

cd07380
Location:9 → 91

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:304 → 396

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:189 → 284

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_017318297.2 → XP_017173786.1 CWF19-like protein 1 isoform X1

UniProtKB/Swiss-Prot

Q8CI33

Conserved Domains (3) summary

cd07380
Location:9 → 91

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:304 → 396

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:189 → 284

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_036161698.1 → XP_036017591.1 CWF19-like protein 1 isoform X2

Conserved Domains (2) summary

pfam04676
Location:197 → 289

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:82 → 177

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_030251087.2 → XP_030106947.1 CWF19-like protein 1 isoform X2

Conserved Domains (2) summary

pfam04676
Location:197 → 289

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:82 → 177

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_030251086.2 → XP_030106946.1 CWF19-like protein 1 isoform X2

Conserved Domains (2) summary

pfam04676
Location:197 → 289

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:82 → 177

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_030251085.2 → XP_030106945.1 CWF19-like protein 1 isoform X2

Conserved Domains (2) summary

pfam04676
Location:197 → 289

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:82 → 177

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_036161697.1 → XP_036017590.1 CWF19-like protein 1 isoform X2

Conserved Domains (2) summary

pfam04676
Location:197 → 289

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:82 → 177

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
XM_011247357.2 → XP_011245659.1 CWF19-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_011245659.1

UniProtKB/Swiss-Prot

Q8CI33

Conserved Domains (3) summary

cd07380
Location:9 → 91

MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain

pfam04676
Location:304 → 396

CwfJ_C_2; Protein similar to CwfJ C-terminus 2

cl00228
Location:189 → 284

HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...