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    Gpr141b G protein-coupled receptor 141B [ Mus musculus (house mouse) ]

    Gene ID: 319293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr141bprovided by MGI
    Official Full Name
    G protein-coupled receptor 141Bprovided by MGI
    Primary source
    MGI:MGI:2441809
    See related
    Ensembl:ENSMUSG00000047462 AllianceGenome:MGI:2441809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Karma; A530099J19Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Orthologous to human GPR141BP (G protein-coupled receptor 141B, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 1.6), mammary gland adult (RPKM 1.5) and 8 other tissues See more
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    Genomic context

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    See Gpr141b in Genome Data Viewer
    Location:
    13 A2; 13 7.03 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (19911587..19917125, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (19727417..19732955, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33801 Neighboring gene secreted frizzled-related protein 4 Neighboring gene NME/NM23 family member 8 Neighboring gene G protein-coupled receptor 141 Neighboring gene STARR-positive B cell enhancer mm9_chr13:19879801-19880102 Neighboring gene STARR-seq mESC enhancer starr_33802 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33803 Neighboring gene STARR-seq mESC enhancer starr_33804 Neighboring gene predicted gene 5446

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Profiling MHC II immunopeptidome of blood-stage malaria reveals that cDC1 control the functionality of parasite-specific CD4 T cells. Draheim M, et al. EMBO Mol Med, 2017 Nov. PMID 28935714, Free PMC Article
    2. Chronic Type I IFN Is Sufficient To Promote Immunosuppression through Accumulation of Myeloid-Derived Suppressor Cells. Taleb K, et al. J Immunol, 2017 Feb 1. PMID 28003378
    3. XCR1+ dendritic cells promote memory CD8+ T cell recall upon secondary infections with Listeria monocytogenes or certain viruses. Alexandre YO, et al. J Exp Med, 2016 Jan 11. PMID 26694969, Free PMC Article
    4. Novel Cre-Expressing Mouse Strains Permitting to Selectively Track and Edit Type 1 Conventional Dendritic Cells Facilitate Disentangling Their Complexity in vivo. Mattiuz R, et al. Front Immunol, 2018. PMID 30564233, Free PMC Article
    5. Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8(+) T cells. Ghilas S, et al. iScience, 2021 Sep 24. PMID 34568787, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 
    • Targeted (2)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175688.4 → NP_783619.2  G protein-coupled receptor-like

      See identical proteins and their annotated locations for NP_783619.2

      Status: VALIDATED

      Source sequence(s)
      AC153016
      UniProtKB/TrEMBL
      B9EKH0, Q8BLT7
      Related
      ENSMUSP00000158601.2, ENSMUST00000151029.3
      Conserved Domains (2) summary
      cd14964
      Location:31 → 55
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:29 → 299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      19911587..19917125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516692.4 → XP_006516755.1  G protein-coupled receptor-like isoform X1

      See identical proteins and their annotated locations for XP_006516755.1

      UniProtKB/TrEMBL
      B9EKH0, Q8BLT7
      Conserved Domains (2) summary
      cd14964
      Location:31 → 55
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:29 → 299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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