Ccdc170 coiled-coil domain containing 170 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccdc170provided by MGI
Official Full Name: coiled-coil domain containing 170provided by MGI
Primary source: MGI:MGI:2685067
See related: Ensembl:ENSMUSG00000019767 AllianceGenome:MGI:2685067
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm221
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in cell junction. Predicted to be active in Golgi apparatus. Orthologous to human CCDC170 (coiled-coil domain containing 170). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 2.06 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (4432312..4514498)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (4482515..4564498)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype.
Title: Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coiled-coil domain-containing protein 170

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195672.2 → NP_001182601.1 coiled-coil domain-containing protein 170 isoform 2

Status: VALIDATED

Source sequence(s)

AC156275, AC158617

Consensus CDS

CCDS56677.1

UniProtKB/TrEMBL

F6ST92

Related

ENSMUSP00000019901.6, ENSMUST00000019901.7

Conserved Domains (1) summary

COG1196
Location:28 → 652

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_001370992.1 → NP_001357921.1 coiled-coil domain-containing protein 170 isoform 1

Status: VALIDATED

Source sequence(s)

AC156275, AC158617

Consensus CDS

CCDS87950.1

UniProtKB/TrEMBL

D3YXL0

Related

ENSMUSP00000115997.2, ENSMUST00000138112.8

Conserved Domains (1) summary

COG1196
Location:34 → 658

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_001370993.1 → NP_001357922.1 coiled-coil domain-containing protein 170 isoform 3

Status: VALIDATED

Source sequence(s)

AC156275, AC158617

Conserved Domains (2) summary

COG1196
Location:123 → 493

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR03346
Location:434 → 566

chaperone_ClpB; ATP-dependent chaperone ClpB

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

4432312..4514498

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155445.1 → XP_036011338.1 coiled-coil domain-containing protein 170 isoform X1

Conserved Domains (2) summary

COG1196
Location:60 → 338

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:251 → 563

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_017313751.2 → XP_017169240.1 coiled-coil domain-containing protein 170 isoform X2

Conserved Domains (1) summary

COG1196
Location:38 → 371

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]