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    Nav2 neuron navigator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171563, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nav2provided by RGD
    Official Full Name
    neuron navigator 2provided by RGD
    Primary source
    RGD:619778
    See related
    EnsemblRapid:ENSRNOG00000014530 AllianceGenome:RGD:619778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rainb1
    Summary
    Predicted to enable 3'-5' DNA helicase activity and heparin binding activity. Involved in nervous system development. Predicted to be located in interstitial matrix and nucleoplasm. Orthologous to human NAV2 (neuron navigator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 118.4), Lung (RPKM 84.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nav2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (107799968..108458546)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (98957629..99322339)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (104575765..104941554)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene RAN, member RAS oncogene family, pseudogene 2 Neighboring gene uncharacterized LOC134483127 Neighboring gene uncharacterized LOC134483134 Neighboring gene uncharacterized LOC134484893 Neighboring gene developing brain homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos. Merrill RA, et al. Proc Natl Acad Sci U S A, 2002 Mar 19. PMID 11904404, Free PMC Article
    2. Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development. McNeill EM, et al. Dev Biol, 2011 May 15. PMID 21419114, Free PMC Article
    3. Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. Peeters PJ, et al. Brain Res Dev Brain Res, 2004 Jun 21. PMID 15158073
    4. Nav2 is necessary for cranial nerve development and blood pressure regulation. McNeill EM, et al. Neural Dev, 2010 Feb 25. PMID 20184720, Free PMC Article
    5. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos
      Title: A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glossopharyngeal nerve development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within optic nerve development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of systemic arterial blood pressure by baroreceptor feedback ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vagus nerve development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in interstitial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neuron navigator 2
    Names
    retinoic acid inducible in neuroblastoma cells 1
    NP_612538.1
    XP_017444230.1
    XP_063134070.1
    XP_063134105.1
    XP_063134130.1
    XP_063134159.1
    XP_063134191.1
    XP_063134221.1
    XP_063134246.1
    XP_063134274.1
    XP_063134333.1
    XP_063134353.1
    XP_063134370.1
    XP_063134395.1
    XP_063134477.1
    XP_063134528.1
    XP_063134552.1
    XP_063134601.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138529.1 → NP_612538.1  neuron navigator 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZQM9
      Related
      ENSRNOP00000074453.4, ENSRNOT00000078477.4
      Conserved Domains (4) summary
      smart00382
      Location:2087 → 2195
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:86 → 187
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2090 → 2177
      AAA_22; AAA domain
      pfam15898
      Location:1844 → 1896
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      107799968..108458546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278060.1 → XP_063134130.1  neuron navigator 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQM9
      Related
      ENSRNOP00000106267.1, ENSRNOT00000156603.1

    2. XM_063278151.1 → XP_063134221.1  neuron navigator 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZQM9

    3. XM_017588741.3 → XP_017444230.1  neuron navigator 2 isoform X1

      UniProtKB/TrEMBL
      F1LR12
      Related
      ENSRNOP00000098226.1, ENSRNOT00000120586.2

    4. XM_063278000.1 → XP_063134070.1  neuron navigator 2 isoform X2

      UniProtKB/TrEMBL
      F1LR12
      Related
      ENSRNOP00000105628.1, ENSRNOT00000158547.1

    5. XM_063278035.1 → XP_063134105.1  neuron navigator 2 isoform X3

      UniProtKB/TrEMBL
      F1LR12
      Related
      ENSRNOP00000087383.3, ENSRNOT00000109728.3

    6. XM_063278204.1 → XP_063134274.1  neuron navigator 2 isoform X9

      UniProtKB/TrEMBL
      F1LR12
      Related
      ENSRNOP00000104067.1, ENSRNOT00000130191.1

    7. XM_063278121.1 → XP_063134191.1  neuron navigator 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A8E6

    8. XM_063278176.1 → XP_063134246.1  neuron navigator 2 isoform X8

      UniProtKB/TrEMBL
      A0A0G2K833, A0A8I6A8E6
      Related
      ENSRNOP00000098228.2, ENSRNOT00000120588.2

    9. XM_063278089.1 → XP_063134159.1  neuron navigator 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZQM9

    10. XM_063278263.1 → XP_063134333.1  neuron navigator 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZQM9

    11. XM_063278283.1 → XP_063134353.1  neuron navigator 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZQM9

    12. XM_063278300.1 → XP_063134370.1  neuron navigator 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZQM9

    13. XM_063278325.1 → XP_063134395.1  neuron navigator 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZQM9

    14. XM_063278407.1 → XP_063134477.1  neuron navigator 2 isoform X12

    15. XM_063278482.1 → XP_063134552.1  neuron navigator 2 isoform X13

    16. XM_063278458.1 → XP_063134528.1  neuron navigator 2 isoform X13

    17. XM_063278531.1 → XP_063134601.1  neuron navigator 2 isoform X14

    RNA

    1. XR_010060052.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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