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    Stard6 StAR-related lipid transfer domain containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291527, updated on 9-Dec-2024

    Summary

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    Symbol
    Stard6provided by RGD
    Full Name
    StAR-related lipid transfer domain containing 6provided by RGD
    Primary source
    RGD:1359639
    See related
    EnsemblRapid:ENSRNOG00000026324 AllianceGenome:RGD:1359639
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lipid binding activity. Orthologous to human STARD6 (StAR related lipid transfer domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 612.2) and Thymus (RPKM 21.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stard6 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (66365526..66393439)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (64089618..64118528)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (68983491..69004868)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482986 Neighboring gene similar to human chromosome 18 open reading frame 54 Neighboring gene DNA polymerase iota Neighboring gene methyl-CpG binding domain protein 2 Neighboring gene uncharacterized LOC134483047 Neighboring gene RNA polymerase II, I and III subunit K, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A comparison of the steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing 6 on the brain and testes between young and aged rats. Chang IY, et al. Acta Histochem, 2014 May. PMID 24360190
    2. Acute responses of DNA repair proteins and StarD6 in rat hippocampus after domoic acid-induced excitotoxicity. Chang IY, et al. Acta Histochem, 2013 Apr. PMID 22883302
    3. Immunolocalization of steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing proteins in the developing cerebellum of normal and hypothyroid rats. Chang IY, et al. J Chem Neuroanat, 2012 Jan. PMID 22024186
    4. The changed immunoreactivity of StarD6 after pilocarpine-induced epilepsy. Chang IY, et al. Neuroreport, 2009 Jul 1. PMID 19434006
    5. Immunohistochemical detection of StarD6 in the rat nervous system. Chang IY, et al. Neuroreport, 2007 Oct 8. PMID 17885612

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. StarD6 might also play a role for neurosteroidogenesis in the hippocampus of aged rats
      Title: A comparison of the steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing 6 on the brain and testes between young and aged rats.
    2. The StarD6 may not be closely related with DNA repair proteins in the hippocampus after domoic acid-induced excitotoxicity, although the activities of these proteins might be positively affected by excitotoxic stimuli.
      Title: Acute responses of DNA repair proteins and StarD6 in rat hippocampus after domoic acid-induced excitotoxicity.
    3. These results suggest that StarD6 may affect the development of Purkinje cells during the first and second postnatal weeks, a known period of thyroid hormone action.
      Title: Immunolocalization of steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing proteins in the developing cerebellum of normal and hypothyroid rats.
    4. morphological aspects of StarD6 were significantly different from those of StAR in cultured glial and neuronal cells, as well as the distribution in the normal and epileptic rat hippocampus
      Title: Does the StarD6 mark the same as the StAR in the nervous system?
    5. StarD6 might have nuclear roles and contribute to subsequent formation of neuroprotective steroids after excitotoxic brain injury.
      Title: The changed immunoreactivity of StarD6 after pilocarpine-induced epilepsy.
    6. StarD6 might play an important role in lipid sensing of the nervous system
      Title: Immunohistochemical detection of StarD6 in the rat nervous system.
    7. StarD6 may play a pivotal role, not only in the spermatogenesis of normal rats, but also in the steroidogenesis of Leydig cells under perinatal hypothyroidism
      Title: The changed immunolocalization of START-domain-containing 6 (StarD6) during the development of testes in rat perinatal hypothyroidism.
    8. In situ hybridization showed Stard6 mRNA expression to be germ cell-specific and expressed only during the maturation stages of round and elongated spermatids of adult rat testis.
      Title: Expression of the putative sterol binding protein Stard6 gene is male germ cell specific.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC93858

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    stAR-related lipid transfer protein 6
    Names
    STAR-related lipid transfer (START) domain containing protein 6
    START domain containing protein 6
    StAR-related lipid transfer (START) domain containing 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007627.1 → NP_001007628.1  stAR-related lipid transfer protein 6

      See identical proteins and their annotated locations for NP_001007628.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078976
      UniProtKB/TrEMBL
      Q5DNW2, Q6AYN5
      Related
      ENSRNOP00000002969.5, ENSRNOT00000002969.6
      Conserved Domains (1) summary
      cl14643
      Location:1 → 204
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      66365526..66393439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096655.2 → XP_038952583.1  stAR-related lipid transfer protein 6 isoform X2

      Conserved Domains (1) summary
      cl14643
      Location:1 → 160
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    2. XM_008772112.4 → XP_008770334.1  stAR-related lipid transfer protein 6 isoform X1

      See identical proteins and their annotated locations for XP_008770334.1

      UniProtKB/TrEMBL
      Q5DNW2, Q6AYN5
      Conserved Domains (1) summary
      cl14643
      Location:1 → 204
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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