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    Sri sorcin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683667, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sriprovided by RGD
    Official Full Name
    sorcinprovided by RGD
    Primary source
    RGD:1584485
    See related
    EnsemblRapid:ENSRNOG00000049780 AllianceGenome:RGD:1584485
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including calcium ion binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in heart development. Located in several cellular components, including T-tubule; Z disc; and dendritic spine neck. Biomarker of congestive heart failure. Orthologous to human SRI (sorcin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 342.8), Spleen (RPKM 305.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sri in Genome Data Viewer
    Location:
    4q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (26928338..26952980, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (25973493..25997879, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (23004657..23029233, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 22 Neighboring gene transfer RNA proline (anticodon AGG) 72 Neighboring gene uncharacterized LOC120102223 Neighboring gene uncharacterized LOC134486721 Neighboring gene STEAP4 metalloreductase Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A systematic survey of repetitive sequences abundantly expressed in rat tumors. Kohnoe S, et al. Biochim Biophys Acta, 1987 Jul 14. PMID 3593728
    2. Sorcin modulates mitochondrial Ca(2+) handling and reduces apoptosis in neonatal rat cardiac myocytes. Suarez J, et al. Am J Physiol Cell Physiol, 2013 Feb 1. PMID 23151801, Free PMC Article
    3. Defective Ca(2+) handling proteins regulation during heart failure. Hu ST, et al. Physiol Res, 2011. PMID 20945956
    4. Ultrastructural localization of sorcin, a 22 kDa calcium binding protein, in the rat caudate-putamen nucleus: association with ryanodine receptors and intracellular calcium release. Pickel VM, et al. J Comp Neurol, 1997 Oct 6. PMID 9378856
    5. N-methyl-D-aspartate receptor 1 in the caudate-putamen nucleus: ultrastructural localization and co-expression with sorcin, a 22,000 mol. wt calcium binding protein. Gracy KN, et al. Neuroscience, 1999 Apr. PMID 10188938

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sorcin prevented 2-deoxyglucose-induced cytochrome c release.
      Title: Sorcin modulates mitochondrial Ca(2+) handling and reduces apoptosis in neonatal rat cardiac myocytes.
    2. Together with a dense distribution in the perimeter of the cell along a pool of RyRs, these properties make sorcin a viable candidate to modulate vascular tone in smooth muscle.
      Title: Sorcin modulation of Ca2+ sparks in rat vascular smooth muscle cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188318

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic sequestering of transcription factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle cell contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell communication by electrical coupling involved in cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of high voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of relaxation of muscle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromaffin granule membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorcin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128190.1 → NP_001121662.1  sorcin

      See identical proteins and their annotated locations for NP_001121662.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158845
      UniProtKB/TrEMBL
      A0A8I5ZTT7, B0BNJ1
      Related
      ENSRNOP00000081785.2, ENSRNOT00000094260.2
      Conserved Domains (2) summary
      cd00051
      Location:75 → 130
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:112 → 161
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      26928338..26952980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236007.5 → XP_006236069.1  sorcin isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTT7, A0A8I5ZWU9
      Related
      ENSRNOP00000066499.3, ENSRNOT00000073790.4
      Conserved Domains (2) summary
      cd00051
      Location:60 → 115
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:97 → 146
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_039108350.2 → XP_038964278.1  sorcin isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTT7
      Related
      ENSRNOP00000083569.2, ENSRNOT00000112226.2
      Conserved Domains (1) summary
      cd16187
      Location:47 → 211
      EFh_PEF_sorcin; Penta-EF hand, calcium binding motifs, found in sorcin

    3. XM_039108351.2 → XP_038964279.1  sorcin isoform X3

      Conserved Domains (2) summary
      cd15897
      Location:74 → 102
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:74 → 108
      EFh_PEF; The penta-EF hand (PEF) family

    4. XM_063286687.1 → XP_063142757.1  sorcin isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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