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    Mdfic MyoD family inhibitor domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mdficprovided by RGD
    Official Full Name
    MyoD family inhibitor domain containingprovided by RGD
    Primary source
    RGD:1309532
    See related
    EnsemblRapid:ENSRNOG00000053787 AllianceGenome:RGD:1309532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kdt1
    Summary
    Predicted to enable Tat protein binding activity and cyclin binding activity. Predicted to be involved in several processes, including negative regulation of protein import into nucleus; regulation of DNA-templated transcription; and regulation of signal transduction. Predicted to be active in cytoplasm and nucleolus. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human MDFIC (MyoD family inhibitor domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 97.3), Heart (RPKM 66.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mdfic in Genome Data Viewer
    Location:
    4q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (44938301..45018157)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (43972310..44052162)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (42202546..42282499)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486732 Neighboring gene Rbmx like 1B Neighboring gene U2 spliceosomal RNA Neighboring gene adenylate kinase 2, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sequence requirement for the nucleolar localization of human I-mfa domain-containing protein (HIC p40). Thébault S, et al. Eur J Cell Biol, 2000 Nov. PMID 11139147
    2. Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity. Gautier VW, et al. Proc Natl Acad Sci U S A, 2005 Nov 8. PMID 16260749, Free PMC Article
    3. The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Young TM, et al. Mol Cell Biol, 2003 Sep. PMID 12944466, Free PMC Article
    4. I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. Kusano S, et al. Mol Cell Biol, 2002 Sep. PMID 12192039, Free PMC Article
    5. Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression. Thébault S, et al. J Biol Chem, 2000 Feb 18. PMID 10671520

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Tat protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myoD family inhibitor domain-containing protein
    Names
    MyoD family inhibitor domain containing protein
    kidney cell line derived transcript 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105668.1 → NP_001099138.1  myoD family inhibitor domain-containing protein

      See identical proteins and their annotated locations for NP_001099138.1

      Status: VALIDATED

      Source sequence(s)
      AC097143, AI029676, CB325630, CB785173, CV106654, DN932316, DV725464
      UniProtKB/TrEMBL
      A6IE11, D3ZVM7
      Related
      ENSRNOP00000073480.1, ENSRNOT00000082453.3
      Conserved Domains (1) summary
      pfam15316
      Location:74 → 247
      MDFI; MyoD family inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      44938301..45018157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107770.2 → XP_038963698.1  myoD family inhibitor domain-containing protein isoform X4

      Conserved Domains (1) summary
      pfam15316
      Location:73 → 154
      MDFI; MyoD family inhibitor

    2. XM_006236103.5 → XP_006236165.1  myoD family inhibitor domain-containing protein isoform X2

      Conserved Domains (1) summary
      pfam15316
      Location:74 → 167
      MDFI; MyoD family inhibitor

    3. XM_039107769.2 → XP_038963697.1  myoD family inhibitor domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y5P6
      Related
      ENSRNOP00000076900.1, ENSRNOT00000109211.2
      Conserved Domains (1) summary
      pfam15316
      Location:74 → 162
      MDFI; MyoD family inhibitor

    4. XM_006236102.5 → XP_006236164.1  myoD family inhibitor domain-containing protein isoform X1

      Conserved Domains (1) summary
      pfam15316
      Location:73 → 246
      MDFI; MyoD family inhibitor
    Nucleotide Protein Strain
    Heading Accession and Version

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