Bcl10 BCL10, immune signaling adaptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bcl10provided by RGD
Official Full Name: BCL10, immune signaling adaptorprovided by RGD
Primary source: RGD:620544
See related: EnsemblRapid:ENSRNOG00000042389 AllianceGenome:RGD:620544
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including CARD domain binding activity; NF-kappaB binding activity; and enzyme binding activity. Predicted to contribute to kinase activator activity. Involved in positive regulation of apoptotic process. Part of protein-containing complex. Human ortholog(s) of this gene implicated in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; immunodeficiency 37; malignant mesothelioma; and non-Hodgkin lymphoma. Orthologous to human BCL10 (BCL10 immune signaling adaptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 175.0), Spleen (RPKM 146.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (237501181..237510821)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (234840880..234850520)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (251805392..251814957)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CARD domain binding	ISO Inferred from Sequence Orthology more info
enables NF-kappaB binding	IBA Inferred from Biological aspect of Ancestor more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables NF-kappaB binding	ISS Inferred from Sequence or Structural Similarity more info
enables general transcription initiation factor binding	ISO Inferred from Sequence Orthology more info
enables general transcription initiation factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
contributes_to kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to kinase activator activity	ISO Inferred from Sequence Orthology more info
contributes_to kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase B binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase B binding	ISO Inferred from Sequence Orthology more info
enables protein kinase B binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within B cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B cell apoptotic process	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within T cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in antifungal innate immune response	ISO Inferred from Sequence Orthology more info
involved_in antifungal innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular defense response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lipopolysaccharide-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mature B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mature B cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in response to food	ISO Inferred from Sequence Orthology more info
involved_in response to food	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to fungus	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CBM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CBM complex	ISO Inferred from Sequence Orthology more info
part_of CBM complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of polkadots	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: B-cell lymphoma/leukemia 10

Names: B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; R-RCD1; RCD; bcl-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.