ADRB3 adrenoceptor beta 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADRB3provided by HGNC
Official Full Name: adrenoceptor beta 3provided by HGNC
Primary source: HGNC:HGNC:288
See related: Ensembl:ENSG00000188778 MIM:109691; AllianceGenome:HGNC:288
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BETA3AR
Summary: The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]
Expression: Biased expression in ovary (RPKM 4.0), placenta (RPKM 1.7) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p11.23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (37962990..37966599, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (38239389..38242998, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (37820508..37824117, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association between rs4994 variant in beta3-Adrenergic receptor and obesity in Vietnamese preschool-age children, independent of eating behaviors.
Title: Association between rs4994 variant in β3-Adrenergic receptor and obesity in Vietnamese preschool-age children, independent of eating behaviors.
Urinary beta 3-adrenoceptor as a diagnostic biomarker for overactive bladder in women.
Title: Urinary beta 3-adrenoceptor as a diagnostic biomarker for overactive bladder in women.
Effects of the Trp64Arg Polymorphism in the ADRB3 Gene on Body Composition, Cardiorespiratory Fitness, and Physical Activity in Healthy Adults.
Title: Effects of the Trp64Arg Polymorphism in the ADRB3 Gene on Body Composition, Cardiorespiratory Fitness, and Physical Activity in Healthy Adults.
The beta3 adrenoceptor in proliferative retinopathies: "Cinderella" steps out of its family shadow.
Title: The β3 adrenoceptor in proliferative retinopathies: "Cinderella" steps out of its family shadow.
beta3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.
Title: β3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.
Association of an ADRB3 Variant with Coronary Artery Disease Within the Chinese Han Population: Construction of a Predictive Nomogram Model.
Title: Association of an ADRB3 Variant with Coronary Artery Disease Within the Chinese Han Population: Construction of a Predictive Nomogram Model.
Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven Hypertension.
Title: Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven Hypertension.
Development of a genetic risk score for obesity predisposition evaluation.
Title: Development of a genetic risk score for obesity predisposition evaluation.
The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis.
Title: The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis.
ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells.
Title: ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells.

Submit: New GeneRIF Correction See all GeneRIFs (228)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Inherited obesity MedGen: C4054476 OMIM: 601665 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-9207 (e-PCR)
- UniSTS:14848

PMC310777P4 (e-PCR)
- UniSTS:272688

D8S2331 (e-PCR)
- UniSTS:68951

NoName (e-PCR)
- UniSTS:486502

ADRB3 (e-PCR)
- UniSTS:506234

PMC164531P1 (e-PCR)
- UniSTS:271495

MARC_68773-68774:1209743884:2 (e-PCR)
- UniSTS:528345

NoName (e-PCR)
- UniSTS:482279

ADRB3_418 (e-PCR)
- UniSTS:276980

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables beta-3 adrenergic receptor binding	IEA Inferred from Electronic Annotation more info
enables beta-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables beta3-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta3-adrenergic receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables epinephrine binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to norepinephrine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in diet induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in eating behavior	IEA Inferred from Electronic Annotation more info
involved_in energy reserve metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in generation of precursor metabolites and energy	TAS Traceable Author Statement more info	PubMed
involved_in heat generation	IEA Inferred from Electronic Annotation more info
NOT involved_in negative regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
NOT involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cold	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: beta-3 adrenergic receptor

Names: adrenergic, beta-3-, receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011936.1 RefSeqGene

Range

5068..8677

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000025.3 → NP_000016.1 beta-3 adrenergic receptor

See identical proteins and their annotated locations for NP_000016.1

Status: REVIEWED

Source sequence(s)

AC144573, BQ024407, DA904248, X70811

Consensus CDS

CCDS6099.1

UniProtKB/Swiss-Prot

P13945, Q4JFT4

UniProtKB/TrEMBL

A8KAG8, B8X6N0, B8X6N1

Related

ENSP00000343782.3, ENST00000345060.5

Conserved Domains (2) summary

cd14964
Location:73 → 95

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:51 → 356

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily