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    Bicdl2 BICD family like cargo adaptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 212733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bicdl2provided by MGI
    Official Full Name
    BICD family like cargo adaptor 2provided by MGI
    Primary source
    MGI:MGI:2388267
    See related
    Ensembl:ENSMUSG00000043782 AllianceGenome:MGI:2388267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BICDR-2; Ccdc64b
    Summary
    Enables small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and vesicle transport along microtubule. Orthologous to human BICDL2 (BICD family like cargo adaptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon adult (RPKM 5.0), stomach adult (RPKM 4.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bicdl2 in Genome Data Viewer
    Location:
    17 A3.3; 17 11.95 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23863663..23887595)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23644605..23668621)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 39-like pseudogene Neighboring gene matrix metallopeptidase 25 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8656 Neighboring gene THO complex 6 Neighboring gene host cell factor C1 regulator 1 (XPO1-dependent) Neighboring gene tumor necrosis factor receptor superfamily, member 12a Neighboring gene claudin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. Schlager MA, et al. EMBO J, 2010 May 19. PMID 20360680, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC47347

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to secretory granule transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BICD family-like cargo adapter 2
    Names
    BICD-related protein 2
    bicaudal D-related protein 2
    coiled-coil domain containing 64B
    coiled-coil domain-containing protein 64B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153784.3 → NP_722479.1  BICD family-like cargo adapter 2

      See identical proteins and their annotated locations for NP_722479.1

      Status: VALIDATED

      Source sequence(s)
      AC154766, AK133729
      Consensus CDS
      CCDS28453.1
      UniProtKB/Swiss-Prot
      Q8CB50, Q8CHW5
      UniProtKB/TrEMBL
      A0A3B2WCI5
      Related
      ENSMUSP00000053808.9, ENSMUST00000062967.10
      Conserved Domains (2) summary
      TIGR02168
      Location:53 → 298
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:165 → 472
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      23863663..23887595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249622.2 → XP_030105482.1  BICD family-like cargo adapter 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8CB50, Q8CHW5
      UniProtKB/TrEMBL
      A0A3B2WCI5
      Conserved Domains (2) summary
      TIGR02168
      Location:53 → 298
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:165 → 472
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. XM_006523985.5 → XP_006524048.1  BICD family-like cargo adapter 2 isoform X1

      UniProtKB/TrEMBL
      A0A3B2WCI5
      Related
      ENSMUSP00000156538.2, ENSMUST00000233541.2
      Conserved Domains (2) summary
      TIGR02168
      Location:36 → 254
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:121 → 428
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHW5.1 GenPept UniProtKB/Swiss-Prot:Q8CHW5

    Gene LinkOut

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