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    Zscan10 zinc finger and SCAN domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 332221, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zscan10provided by MGI
    Official Full Name
    zinc finger and SCAN domain containing 10provided by MGI
    Primary source
    MGI:MGI:3040700
    See related
    Ensembl:ENSMUSG00000023902 AllianceGenome:MGI:3040700
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp206; Znf206; Zkscan10
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; limb mesenchyme; and nervous system. Orthologous to human ZSCAN10 (zinc finger and SCAN domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.9), cerebellum adult (RPKM 0.3) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zscan10 in Genome Data Viewer
    Location:
    17 A3.3; 17 11.79 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23819800..23829993)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23600826..23611019)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330415G19 gene Neighboring gene STARR-positive B cell enhancer ABC_E9944 Neighboring gene zinc finger protein 213 Neighboring gene zinc finger protein 13 Neighboring gene STARR-seq mESC enhancer starr_42052 Neighboring gene STARR-seq mESC enhancer starr_42053 Neighboring gene STARR-seq mESC enhancer starr_42054 Neighboring gene calcium binding protein 39-like pseudogene Neighboring gene matrix metallopeptidase 25 Neighboring gene ribosomal protein L36 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zscan10 is dispensable for maintenance of pluripotency in mouse embryonic stem cells. Yamane M, et al. Biochem Biophys Res Commun, 2015 Dec 25. PMID 26592664
    2. Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206. Liang Y, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Apr 1. PMID 22505416, Free PMC Article
    3. ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial malformations. Laugwitz L, et al. Brain, 2024 Jul 5. PMID 38386308, Free PMC Article
    4. Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin. Yanagihara Y, et al. Bone, 2019 May. PMID 30771488
    5. ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. Skamagki M, et al. Nat Cell Biol, 2017 Sep. PMID 28846095, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial malformations.
      Title: ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial malformations.
    2. Zscan10 negatively regulates osteoclast differentiation through transcription of Hp.
      Title: Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin.
    3. The pluripotency factor ZSCAN10 is poorly expressed in A-iPSCs and addition of ZSCAN10 to the four Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) during A-iPSC reprogramming normalizes ROS-glutathione homeostasis and the DNA damage response, and recovers genomic stability.
      Title: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors.
    4. Our results clearly indicate that Zscan10 is dispensable for the ability of self-renewal and differentiation in ES cells.
      Title: Zscan10 is dispensable for maintenance of pluripotency in mouse embryonic stem cells.
    5. a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof
      Title: Pleiotropic functions for transcription factor zscan10.
    6. Optimized crystals diffracted to 1.85 A resolution and belonged to space group I422, with unit-cell parameters a = 67.57, c = 87.54 A. A Matthews analysis indicated the presence of one Zfp206SCAN molecule per asymmetric unit
      Title: Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206.
    7. Zfp206 is a key component of the transcriptional regulatory network and together with Oct4 and Sox2 regulates differentiation of embryonic stem cells.
      Title: Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells.
    8. Zfp206 is an embryonic transcription factor that plays a role in regulating pluripotency of embryonic stem cells.
      Title: Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells.
    9. Zfp206 is a regulator of embryonic stem cell differentiation that controls a set of genes expressed very early in development, most of which themselves appear to be regulators.
      Title: Zfp206 regulates ES cell gene expression and differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2)  1 citation
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stem cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 10
    Names
    zinc finger and SCAN domains 10
    zinc finger protein 206
    zinc finger with KRAB and SCAN domains 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033425.4 → NP_001028597.2  zinc finger and SCAN domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_001028597.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC154766, AK141259, BM933809, BX526901, CF896527
      Consensus CDS
      CCDS28451.1
      UniProtKB/Swiss-Prot
      B7ZP53, Q20D61, Q20D62, Q20D63, Q3URR7
      Related
      ENSMUSP00000093255.3, ENSMUST00000095595.9
      Conserved Domains (6) summary
      cd07936
      Location:39 → 123
      SCAN; SCAN oligomerization domain
      COG5048
      Location:366 → 767
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:639 → 659
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:754 → 776
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:679 → 704
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:592 → 643
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    2. NM_001289481.1 → NP_001276410.1  zinc finger and SCAN domain-containing protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001276410.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 3' coding region, compared to variant 1. This results in an isoform (2) that is shorter, compared to isoform 1.
      Source sequence(s)
      AC154766, AK141259, BM933809, BX526901, CD539380, CF896527
      Consensus CDS
      CCDS70766.1
      UniProtKB/Swiss-Prot
      Q3URR7
      Related
      ENSMUSP00000113386.2, ENSMUST00000120967.8
      Conserved Domains (6) summary
      cd07936
      Location:39 → 123
      SCAN; SCAN oligomerization domain
      COG5048
      Location:318 → 735
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:607 → 627
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:722 → 744
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:647 → 672
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:560 → 611
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    3. NM_001289482.1 → NP_001276411.1  zinc finger and SCAN domain-containing protein 10 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region, compared to variant 1. This results in an isoform (3) that is shorter, compared to isoform 1.
      Source sequence(s)
      AC154766, AK141259, BM933809, BX526901, CF896527
      Consensus CDS
      CCDS79510.1
      UniProtKB/Swiss-Prot
      Q3URR7
      Related
      ENSMUSP00000111171.2, ENSMUST00000115509.8
      Conserved Domains (7) summary
      smart00431
      Location:39 → 147
      SCAN; leucine rich region
      cd07936
      Location:39 → 123
      SCAN; SCAN oligomerization domain
      COG5048
      Location:256 → 657
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:529 → 549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:644 → 666
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:569 → 594
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:482 → 533
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    4. NM_001289483.1 → NP_001276412.1  zinc finger and SCAN domain-containing protein 10 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses alternate in-frame splice sites in the 5' and 3' coding region and initiates translation at a downstream start codon, compared to variant 1. This results in an isoform (4) that is shorter, compared to isoform 1.
      Source sequence(s)
      AC154766, AK141259, BM933809, BX526901, CD539380, CF896527
      UniProtKB/Swiss-Prot
      Q3URR7
      Related
      ENSMUSP00000118987.2, ENSMUST00000129227.8
      Conserved Domains (5) summary
      COG5048
      Location:114 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:403 → 423
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:518 → 540
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:443 → 468
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:356 → 407
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    5. NM_001289484.1 → NP_001276413.1  zinc finger and SCAN domain-containing protein 10 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses alternate in-frame splice sites in the 5' and 3' coding region, compared to variant 1. This results in an isoform (5) that is shorter, compared to isoform 1.
      Source sequence(s)
      AC154766, AK141259, BM933809, BX526901, CD539380, CF896527
      UniProtKB/Swiss-Prot
      Q3URR7
      Related
      ENSMUSP00000120876.2, ENSMUST00000148062.8
      Conserved Domains (6) summary
      cd07936
      Location:39 → 127
      SCAN; SCAN oligomerization domain
      COG5048
      Location:273 → 690
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:562 → 582
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:677 → 699
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:602 → 627
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:515 → 566
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      23819800..23829993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3URR7.2 GenPept UniProtKB/Swiss-Prot:Q3URR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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