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    Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif 14 [ Mus musculus (house mouse) ]

    Gene ID: 237360, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Adamts14provided by MGI
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 14provided by MGI
    Primary source
    MGI:MGI:2179942
    See related
    Ensembl:ENSMUSG00000059901 AllianceGenome:MGI:2179942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TS14; Adamts-14
    Summary
    Enables peptidase activity. Acts upstream of or within collagen fibril organization. Located in extracellular region. Is expressed in vertebral axis musculature. Human ortholog(s) of this gene implicated in osteoarthritis; primary progressive multiple sclerosis; and relapsing-remitting multiple sclerosis. Orthologous to human ADAMTS14 (ADAM metallopeptidase with thrombospondin type 1 motif 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 4.5), spleen adult (RPKM 3.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adamts14 in Genome Data Viewer
    Location:
    10 B4; 10 32.16 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61032886..61109447, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61197112..61273419, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene sphingosine phosphate lyase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8337 Neighboring gene STARR-positive B cell enhancer mm9_chr10:60610293-60610594 Neighboring gene STARR-seq mESC enhancer starr_26826 Neighboring gene thymus, brain and testes associated Neighboring gene STARR-positive B cell enhancer mm9_chr10:60662268-60662569 Neighboring gene predicted gene, 29861 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:60697146-60697393 Neighboring gene ribosomal protein L27A, pseudogene 1 Neighboring gene perforin 1 (pore forming protein)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene. Kentistou KA, et al. Nat Commun, 2023 Jan 19. PMID 36658113, Free PMC Article
    2. ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for pro-VEGFC activation and lymphatic homeostasis. Dupont L, et al. JCI Insight, 2022 Apr 22. PMID 35316211, Free PMC Article
    3. Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14. Dupont L, et al. Matrix Biol, 2018 Sep. PMID 29649548
    4. Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function. Carter EP, et al. J Pathol, 2024 Jan. PMID 37929635, Free PMC Article
    5. Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain. Rosell-García T, et al. J Biol Chem, 2019 Jul 19. PMID 31152061, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.
      Title: Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.
    2. Mice lacking Adamts2 and Adamts14 develop spontaneous atopic dermatitis due to immune dysregulation.
      Title: Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within collagen fibril organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 14
    Names
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081127.2 → NP_001074596.1  A disintegrin and metalloproteinase with thrombospondin motifs 14 precursor

      See identical proteins and their annotated locations for NP_001074596.1

      Status: VALIDATED

      Source sequence(s)
      AC123530, AC151895
      Consensus CDS
      CCDS35915.1
      UniProtKB/TrEMBL
      B2RXR8, B2RXX5, E9PX39
      Related
      ENSMUSP00000090143.5, ENSMUST00000092486.11
      Conserved Domains (6) summary
      smart00209
      Location:542 → 594
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:246 → 444
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam00090
      Location:961 → 1008
      TSP_1; Thrombospondin type 1 domain
      pfam01421
      Location:248 → 447
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:80 → 193
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:701 → 816
      ADAM_spacer1; ADAM-TS Spacer 1

    RNA

    1. NR_157278.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC151895, AK137573, AW120521, BC172106

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      61032886..61109447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155775.1 → XP_036011668.1  A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform X1

      UniProtKB/TrEMBL
      B2RXR8
      Conserved Domains (6) summary
      smart00209
      Location:542 → 594
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:246 → 444
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:701 → 816
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:80 → 194
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:459 → 528
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:838 → 893
      TSP1_ADAMTS; Thrombospondin type 1 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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