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    XKRX XK related X-linked [ Homo sapiens (human) ]

    Gene ID: 402415, updated on 10-Dec-2024

    Summary

    Official Symbol
    XKRXprovided by HGNC
    Official Full Name
    XK related X-linkedprovided by HGNC
    Primary source
    HGNC:HGNC:29845
    See related
    Ensembl:ENSG00000182489 MIM:300684; AllianceGenome:HGNC:29845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    XKR2; XRG2; XPLAC
    Summary
    This gene encodes a protein that is related to a component of the XK/Kell complex of the Kell blood group system. The encoded protein includes several transmembrane domains, is known to be exposed to the cell surface, and may function as a membrane transporter. [provided by RefSeq, May 2010]
    Expression
    Broad expression in skin (RPKM 2.6), lymph node (RPKM 0.8) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See XKRX in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (100886916..100959343, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (99329581..99402028, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100168434..100183906, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29805 Neighboring gene cleavage stimulation factor subunit 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 26 Neighboring gene NADPH oxidase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 27 Neighboring gene NANOG hESC enhancer GRCh37_chrX:100150382-100150883 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:100182110-100183309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29806 Neighboring gene NSA2 pseudogene 3 Neighboring gene CSGALNACT2 pseudogene 1 Neighboring gene ARF like GTPase 13A Neighboring gene ReSE screen-validated silencer GRCh37_chrX:100246331-100246526 Neighboring gene tRNA methyltransferase 2 homolog B Neighboring gene uncharacterized LOC124905285

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    XK-related protein 2
    Names
    X Kell blood group precursor-related, X-linked
    X-linked Kx blood group related, X-linked
    XK, Kell blood group complex subunit-related, X-linked
    membrane protein XPLAC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021224.1 RefSeqGene

      Range
      4993..20465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_212559.3NP_997724.2  XK-related protein 2

      See identical proteins and their annotated locations for NP_997724.2

      Status: REVIEWED

      Source sequence(s)
      AI087330, AY589511, Z73417
      Consensus CDS
      CCDS14476.2
      UniProtKB/Swiss-Prot
      B2RNN6, B4DKU2, Q5H9J6, Q6PP77
      Related
      ENSP00000362047.2, ENST00000372956.3
      Conserved Domains (1) summary
      pfam09815
      Location:36407
      XK-related; XK-related protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      100886916..100959343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530954.4XP_011529256.1  XK-related protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011529256.1

      Conserved Domains (1) summary
      pfam09815
      Location:49369
      XK-related; XK-related protein
    2. XM_011530955.2XP_011529257.1  XK-related protein 2 isoform X2

      Conserved Domains (1) summary
      pfam09815
      Location:35291
      XK-related; XK-related protein
    3. XM_017029517.2XP_016885006.1  XK-related protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PP77
      Conserved Domains (1) summary
      pfam09815
      Location:1203
      XK-related; XK-related protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      99329581..99402028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327053.1XP_054183028.1  XK-related protein 2 isoform X1

    2. XM_054327054.1XP_054183029.1  XK-related protein 2 isoform X2

    3. XM_054327055.1XP_054183030.1  XK-related protein 2 isoform X3