ASGR2 asialoglycoprotein receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ASGR2provided by HGNC
Official Full Name: asialoglycoprotein receptor 2provided by HGNC
Primary source: HGNC:HGNC:743
See related: Ensembl:ENSG00000161944 MIM:108361; AllianceGenome:HGNC:743
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2
Summary: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression: Biased expression in liver (RPKM 120.6) and gall bladder (RPKM 6.7) See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17p13.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (7101322..7115146, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (7001999..7016068, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (7004641..7018141, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although gastric cancer cell-invasive activity was significantly decreased by knockdown, forced expression of ASGR2 promoted invasive activity.
Title: Pattern-Specific Transcriptomics Identifies ASGR2 as a Predictor of Hematogenous Recurrence of Gastric Cancer.
PEGylated lipoplexes were well tolerated by both HEK293 (ASGP-R-negative) and HepG2 (ASGP-R-positive) cell lines and delivered DNA to the hepatoma cell line HepG2 by ASGP-R mediation at levels three-fold greater than nonPEGylated lipoplexes.
Title: PEGylation potentiates hepatoma cell targeted liposome-mediated in vitro gene delivery via the asialoglycoprotein receptor.
findings show that the hepatitis E virus (HEV) ORF2 protein interacts directly with the ectodomain of both ASGR1 and ASGR2; ASGPR is involved in and facilitates HEV infection by binding to ORF2
Title: Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2.
the distribution of ASGR in human testis, was investigated.
Title: Expression pattern of asialoglycoprotein receptor in human testis.
sH2a has the potential to be a uniquely sensitive and specific novel marker for liver fibrosis and function.
Title: A secreted form of the asialoglycoprotein receptor, sH2a, as a novel potential noninvasive marker for liver fibrosis.
found that the asialoglycoprotein receptor (ASGPR) is involved in hepatocyte recognition of cells predestined for killing, including activated autologous T lymphocytes
Title: Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor.
Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes.
Title: Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes.
primary renal proximal tubular epithelial cells have a functional ASGPR, consisting of the H1 and H2 subunits, that is capable of specific ligand binding and uptake
Title: Expression of a functional asialoglycoprotein receptor in human renal proximal tubular epithelial cells.
The minor subunit splice variants, H2b and H2c, of the human asialoglycoprotein receptor are present with the major subunit H1 in different hetero-oligomeric receptor complexes
Title: The minor subunit splice variants, H2b and H2c, of the human asialoglycoprotein receptor are present with the major subunit H1 in different hetero-oligomeric receptor complexes.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH80271 (e-PCR)
- UniSTS:87374

STS-T67921 (e-PCR)
- UniSTS:28761

WI-11341 (e-PCR)
- UniSTS:10718

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables D-mannose binding	IBA Inferred from Biological aspect of Ancestor more info
enables asialoglycoprotein receptor activity	TAS Traceable Author Statement more info	PubMed
enables fucose binding	IBA Inferred from Biological aspect of Ancestor more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum quality control compartment	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: asialoglycoprotein receptor 2

Names: C-type lectin domain family 4 member H2; HBxAg-binding protein; hepatic lectin H2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029064.2 RefSeqGene

Range

5324..18820

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181.4 → NP_001172.1 asialoglycoprotein receptor 2 isoform a

See identical proteins and their annotated locations for NP_001172.1

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as H2a, differs in the 5' UTR, compared to variant H2'. Variants H2' and 1 encode the same isoform (a).

Source sequence(s)

AC120057, BX483468, M11025

Consensus CDS

CCDS32544.1

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969

Conserved Domains (2) summary

cd03590
Location:177 → 302

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:29 → 167

Lectin_N; Hepatic lectin, N-terminal domain
NM_001201352.2 → NP_001188281.1 asialoglycoprotein receptor 2 isoform d

See identical proteins and their annotated locations for NP_001188281.1

Status: REVIEWED

Description

Transcript Variant: This variant (4), also known as H2b, differs in the 5' UTR and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant H2'. The encoded isoform (d) is shorter than isoform a.

Source sequence(s)

AC120057, AF529374, BM561839, M11025

Consensus CDS

CCDS92242.1

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969

UniProtKB/TrEMBL

Q7Z4G9

Related

ENSP00000510808.1, ENST00000691900.1

Conserved Domains (2) summary

cd03590
Location:172 → 297

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:37 → 162

Lectin_N; Hepatic lectin, N-terminal domain
NM_080912.3 → NP_550434.1 asialoglycoprotein receptor 2 isoform a

See identical proteins and their annotated locations for NP_550434.1

Status: REVIEWED

Description

Transcript Variant: This variant (H2') represents the longest transcript and encodes the longest isoform (a). Variants H2' and 1 encode the same isoform.

Source sequence(s)

AC120057, DC315727, M11025

Consensus CDS

CCDS32544.1

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969

Related

ENSP00000347140.5, ENST00000355035.9

Conserved Domains (2) summary

cd03590
Location:177 → 302

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:29 → 167

Lectin_N; Hepatic lectin, N-terminal domain
NM_080913.3 → NP_550435.1 asialoglycoprotein receptor 2 isoform b

See identical proteins and their annotated locations for NP_550435.1

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as H2c and L-H2, differs in the 5' UTR and uses two alternate splice sites in the 5' coding region, but maintains the reading frame, compared to variant H2'. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

BC017251, BX483468, M11025

Consensus CDS

CCDS11088.1

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969

Related

ENSP00000254850.7, ENST00000254850.11

Conserved Domains (2) summary

cd03590
Location:153 → 278

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:18 → 143

Lectin_N; Hepatic lectin, N-terminal domain
NM_080914.2 → NP_550436.1 asialoglycoprotein receptor 2 isoform c

See identical proteins and their annotated locations for NP_550436.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region but maintains the reading frame, compared to variant H2'. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AC120057, M11025, U97197, X55284

Consensus CDS

CCDS45598.1

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969

Related

ENSP00000405844.2, ENST00000446679.6

Conserved Domains (2) summary

cd03590
Location:158 → 283

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:18 → 148

Lectin_N; Hepatic lectin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

7101322..7115146 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017024651.2 → XP_016880140.1 asialoglycoprotein receptor 2 isoform X8

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969
XM_047436090.1 → XP_047292046.1 asialoglycoprotein receptor 2 isoform X6

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969
XM_024450755.1 → XP_024306523.1 asialoglycoprotein receptor 2 isoform X4

Conserved Domains (2) summary

cd03590
Location:245 → 370

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:110 → 235

Lectin_N; Hepatic lectin, N-terminal domain
XM_011523862.4 → XP_011522164.2 asialoglycoprotein receptor 2 isoform X1
XM_047436089.1 → XP_047292045.1 asialoglycoprotein receptor 2 isoform X3
XM_006721524.3 → XP_006721587.2 asialoglycoprotein receptor 2 isoform X5

Conserved Domains (2) summary

cd03590
Location:114 → 239

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:21 → 104

Lectin_N; Hepatic lectin, N-terminal domain
XM_011523863.4 → XP_011522165.1 asialoglycoprotein receptor 2 isoform X2

See identical proteins and their annotated locations for XP_011522165.1

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969

Conserved Domains (2) summary

cd03590
Location:165 → 290

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:18 → 155

Lectin_N; Hepatic lectin, N-terminal domain
XM_024450757.2 → XP_024306525.1 asialoglycoprotein receptor 2 isoform X5

Conserved Domains (2) summary

cd03590
Location:114 → 239

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:21 → 104

Lectin_N; Hepatic lectin, N-terminal domain
XM_006721526.3 → XP_006721589.1 asialoglycoprotein receptor 2 isoform X9

See identical proteins and their annotated locations for XP_006721589.1

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969

Conserved Domains (2) summary

cd03590
Location:153 → 278

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:18 → 143

Lectin_N; Hepatic lectin, N-terminal domain
XM_047436091.1 → XP_047292047.1 asialoglycoprotein receptor 2 isoform X8

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969
XM_024450756.2 → XP_024306524.1 asialoglycoprotein receptor 2 isoform X7

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969

UniProtKB/TrEMBL

Q7Z4G9

Conserved Domains (2) summary

cd03590
Location:172 → 297

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:37 → 162

Lectin_N; Hepatic lectin, N-terminal domain
XM_011523864.4 → XP_011522166.1 asialoglycoprotein receptor 2 isoform X6

See identical proteins and their annotated locations for XP_011522166.1

UniProtKB/Swiss-Prot

A6NLV8, A8MT12, D3DTM9, D3DTN0, O00448, P07307, Q03969

Conserved Domains (2) summary

cd03590
Location:184 → 309

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam03954
Location:29 → 174

Lectin_N; Hepatic lectin, N-terminal domain