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    NEK5 NIMA related kinase 5 [ Homo sapiens (human) ]

    Gene ID: 341676, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NEK5provided by HGNC
    Official Full Name
    NIMA related kinase 5provided by HGNC
    Primary source
    HGNC:HGNC:7748
    See related
    Ensembl:ENSG00000197168 MIM:616731; AllianceGenome:HGNC:7748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Predicted to act upstream of or within positive regulation of cysteine-type endopeptidase activity and positive regulation of striated muscle cell differentiation. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 3.0), lung (RPKM 0.4) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See NEK5 in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (52033611..52129073, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (51248427..51343906, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52607747..52703209, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATPase copper transporting beta Neighboring gene fatty acid binding protein 5 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 15635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7786 Neighboring gene ALG11 alpha-1,2-mannosyltransferase Neighboring gene UTP14C small subunit processome component Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52653033-52653791 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52653792-52654549 Neighboring gene Sharpr-MPRA regulatory region 10224 Neighboring gene Sharpr-MPRA regulatory region 2352 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:52696487-52696693 Neighboring gene uncharacterized LOC101929657 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:52706487-52707686 Neighboring gene uncharacterized LOC124903176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5382 Neighboring gene NIMA related kinase 3 Neighboring gene Sharpr-MPRA regulatory region 2809 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 5 Neighboring gene thrombospondin type 1 domain containing 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach. de Castro Ferezin C, et al. Cell Commun Signal, 2022 Dec 22. PMID 36550548, Free PMC Article
    2. Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration. Melo Hanchuk TD, et al. Cell Signal, 2015 Jun. PMID 25725288
    3. Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis. Prosser SL, et al. J Cell Biol, 2015 May 11. PMID 25963817, Free PMC Article
    4. NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells. Matossian MD, et al. Breast Cancer Res Treat, 2021 Aug. PMID 34196902
    5. Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review. Matossian MD, et al. Curr Med Chem, 2021. PMID 33749548

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach.
      Title: Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach.
    2. NEK5 interacts with LonP1 and its kinase activity is essential for the regulation of mitochondrial functions and mtDNA maintenance.
      Title: NEK5 interacts with LonP1 and its kinase activity is essential for the regulation of mitochondrial functions and mtDNA maintenance.
    3. Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review.
      Title: Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review.
    4. NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.
      Title: NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.
    5. Knockdown of lncRNA XIST inhibits hypoxia-induced glycolysis, migration and invasion through regulating miR-381-3p/NEK5 axis in nasopharyngeal carcinoma.
      Title: Knockdown of lncRNA XIST inhibits hypoxia-induced glycolysis, migration and invasion through regulating miR-381-3p/NEK5 axis in nasopharyngeal carcinoma.
    6. NEK5 interacts with topoisomerase IIbeta and is involved in the DNA damage response induced by etoposide.
      Title: NEK5 interacts with topoisomerase IIβ and is involved in the DNA damage response induced by etoposide.
    7. the NEK protein kinases emerge as important proteins in thyroid cancer development and may help to identify malignancy and aggressiveness features during diagnosis.
      Title: Expression of the NEK family in normal and cancer tissue: an immunohistochemical study.
    8. Data show that up-regulated NEK5 was significantly associated with breast tumor progression and poor overall prognosis; and that silencing of NEK5 can significantly suppress the proliferation both in vivo and in vitro, inhibiting migration, and invasion. NEK5 can up-regulate Cyclin A2 by direct interaction.
      Title: NEK5 promotes breast cancer cell proliferation through up-regulation of Cyclin A2.
    9. The hNek5 is mitochondrial localization and its role on cell death and cell respiration defects through COX11, MTX2 and BCLAF1.
      Title: Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration.
    10. Nek5 is required for the loss of centrosome linker proteins and enhanced microtubule nucleation that lead to timely centrosome separation and bipolar spindle formation in mitosis
      Title: Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC75495

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek5
    Names
    NIMA (never in mitosis gene a)-related kinase 5
    nimA-related protein kinase 5
    NP_001352481.1
    NP_954983.1
    XP_006719871.2
    XP_011533368.1
    XP_011533370.1
    XP_016876045.1
    XP_047286243.1
    XP_047286244.1
    XP_047286245.1
    XP_047286246.1
    XP_047286247.1
    XP_047286248.1
    XP_047286249.1
    XP_047286250.1
    XP_047286251.1
    XP_054230467.1
    XP_054230468.1
    XP_054230469.1
    XP_054230470.1
    XP_054230471.1
    XP_054230472.1
    XP_054230473.1
    XP_054230474.1
    XP_054230475.1
    XP_054230476.1
    XP_054230477.1
    XP_054230478.1
    XP_054230479.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365552.1 → NP_001352481.1  serine/threonine-protein kinase Nek5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL139082
      Consensus CDS
      CCDS91811.1
      UniProtKB/TrEMBL
      A0A3B3ITQ6, A0A8I5KQI9
      Related
      ENSP00000509632.1, ENST00000684899.1
      Conserved Domains (1) summary
      cd08225
      Location:3 → 259
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    2. NM_199289.3 → NP_954983.1  serine/threonine-protein kinase Nek5 isoform 1

      See identical proteins and their annotated locations for NP_954983.1

      Status: VALIDATED

      Source sequence(s)
      AL139082, BC063885, HY018243
      Consensus CDS
      CCDS31979.1
      UniProtKB/Swiss-Prot
      Q5TAP5, Q6P3R8
      UniProtKB/TrEMBL
      A0A494C168
      Related
      ENSP00000347767.4, ENST00000355568.8
      Conserved Domains (2) summary
      cd08225
      Location:3 → 259
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
      smart00220
      Location:4 → 259
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      52033611..52129073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430292.1 → XP_047286248.1  serine/threonine-protein kinase Nek5 isoform X6

      UniProtKB/TrEMBL
      A0A3B3ITQ6, A0A8I5KQI9

    2. XM_047430293.1 → XP_047286249.1  serine/threonine-protein kinase Nek5 isoform X7

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    3. XM_047430291.1 → XP_047286247.1  serine/threonine-protein kinase Nek5 isoform X5

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    4. XM_047430290.1 → XP_047286246.1  serine/threonine-protein kinase Nek5 isoform X4

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    5. XM_047430288.1 → XP_047286244.1  serine/threonine-protein kinase Nek5 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    6. XM_047430287.1 → XP_047286243.1  serine/threonine-protein kinase Nek5 isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    7. XM_047430289.1 → XP_047286245.1  serine/threonine-protein kinase Nek5 isoform X3

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    8. XM_047430294.1 → XP_047286250.1  serine/threonine-protein kinase Nek5 isoform X8

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    9. XM_047430295.1 → XP_047286251.1  serine/threonine-protein kinase Nek5 isoform X11

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    10. XM_011535066.3 → XP_011533368.1  serine/threonine-protein kinase Nek5 isoform X10

      UniProtKB/TrEMBL
      A0A494C168
      Conserved Domains (2) summary
      cd08225
      Location:75 → 331
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
      smart00220
      Location:76 → 331
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    11. XM_017020556.2 → XP_016876045.1  serine/threonine-protein kinase Nek5 isoform X9

      UniProtKB/TrEMBL
      A0A494C168

    12. XM_006719808.5 → XP_006719871.2  serine/threonine-protein kinase Nek5 isoform X12

      Conserved Domains (2) summary
      cd08225
      Location:75 → 331
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
      smart00220
      Location:76 → 331
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    13. XM_011535068.3 → XP_011533370.1  serine/threonine-protein kinase Nek5 isoform X13

      Conserved Domains (2) summary
      cd08225
      Location:75 → 331
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
      smart00220
      Location:76 → 331
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RNA

    1. XR_941575.3 RNA Sequence

    2. XR_941574.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      51248427..51343906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374497.1 → XP_054230472.1  serine/threonine-protein kinase Nek5 isoform X6

      UniProtKB/TrEMBL
      A0A3B3ITQ6, A0A8I5KQI9

    2. XM_054374498.1 → XP_054230473.1  serine/threonine-protein kinase Nek5 isoform X7

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    3. XM_054374496.1 → XP_054230471.1  serine/threonine-protein kinase Nek5 isoform X5

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    4. XM_054374495.1 → XP_054230470.1  serine/threonine-protein kinase Nek5 isoform X4

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    5. XM_054374493.1 → XP_054230468.1  serine/threonine-protein kinase Nek5 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    6. XM_054374492.1 → XP_054230467.1  serine/threonine-protein kinase Nek5 isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    7. XM_054374494.1 → XP_054230469.1  serine/threonine-protein kinase Nek5 isoform X3

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    8. XM_054374499.1 → XP_054230474.1  serine/threonine-protein kinase Nek5 isoform X8

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    9. XM_054374502.1 → XP_054230477.1  serine/threonine-protein kinase Nek5 isoform X11

      UniProtKB/TrEMBL
      A0A3B3ITQ6

    10. XM_054374500.1 → XP_054230475.1  serine/threonine-protein kinase Nek5 isoform X9

      UniProtKB/TrEMBL
      A0A494C168

    11. XM_054374501.1 → XP_054230476.1  serine/threonine-protein kinase Nek5 isoform X10

      UniProtKB/TrEMBL
      A0A494C168

    12. XM_054374503.1 → XP_054230478.1  serine/threonine-protein kinase Nek5 isoform X12

    13. XM_054374504.1 → XP_054230479.1  serine/threonine-protein kinase Nek5 isoform X13

    RNA

    1. XR_008488760.1 RNA Sequence

    2. XR_008488761.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P3R8.1 GenPept UniProtKB/Swiss-Prot:Q6P3R8

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