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    Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 98660, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atp1a2provided by MGI
    Official Full Name
    ATPase, Na+/K+ transporting, alpha 2 polypeptideprovided by MGI
    Primary source
    MGI:MGI:88106
    See related
    Ensembl:ENSMUSG00000007097 AllianceGenome:MGI:88106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atpa-3; mKIAA0778
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and alkali metal ion binding activity. Involved in several processes, including locomotory exploration behavior; neurotransmitter uptake; and response to auditory stimulus. Acts upstream of or within several processes, including forebrain development; regulation of blood circulation; and regulation of muscle contraction. Located in T-tubule; cell projection; and neuronal cell body. Part of protein-containing complex. Is active in cell surface; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including genitourinary system; heart; musculature; nervous system; and sensory organ. Used to study familial hemiplegic migraine 2. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; electroclinical syndrome (multiple); hypertension; and migraine with aura (multiple). Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 126.7), frontal lobe adult (RPKM 118.1) and 14 other tissues See more
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    Genomic context

    See Atp1a2 in Genome Data Viewer
    Location:
    1 H3; 1 79.6 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172099276..172125631, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172271709..172298064, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 17224 Neighboring gene STARR-positive B cell enhancer ABC_E630 Neighboring gene calsequestrin 1 Neighboring gene ATPase, Na+/K+ transporting, alpha 4 polypeptide Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_03056 Neighboring gene predicted gene, 57554 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174207398-174207699 Neighboring gene predicted gene, 39704 Neighboring gene STARR-positive B cell enhancer ABC_E5853 Neighboring gene STARR-positive B cell enhancer ABC_E11698 Neighboring gene immunoglobulin superfamily, member 8 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (7)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase-coupled monoatomic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables P-type sodium:potassium-exchanging transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables P-type sodium:potassium-exchanging transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables P-type sodium:potassium-exchanging transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables steroid hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within L-ascorbic acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within amygdala development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood circulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to steroid hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to steroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment or maintenance of transmembrane electrochemical gradient IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular potassium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular potassium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular sodium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of striated muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuronal action potential propagation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neurotransmitter uptake IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter uptake IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within olfactory cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of cardiac muscle cell contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cardiac muscle cell contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of striated muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of the force of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of vasoconstriction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to auditory stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to glycoside IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to glycoside ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to potassium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in organelle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    part_of sodium:potassium-exchanging ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of sodium:potassium-exchanging ATPase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of sodium:potassium-exchanging ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium/potassium-transporting ATPase subunit alpha-2
    Names
    Na(+)/K(+) ATPase alpha(+) subunit
    Na(+)/K(+) ATPase alpha-2 subunit
    sodium pump subunit alpha-2
    NP_848492.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178405.3NP_848492.1  sodium/potassium-transporting ATPase subunit alpha-2

      See identical proteins and their annotated locations for NP_848492.1

      Status: VALIDATED

      Source sequence(s)
      AC087061, AK147331, BY780072
      Consensus CDS
      CCDS35782.1
      UniProtKB/Swiss-Prot
      Q6PIE5, Q80UZ8
      UniProtKB/TrEMBL
      Q3UHK5, Q6ZQ49
      Related
      ENSMUSP00000083077.5, ENSMUST00000085913.11
      Conserved Domains (1) summary
      TIGR01106
      Location:301020
      ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      172099276..172125631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)