Ccna2 cyclin A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccna2provided by MGI
Official Full Name: cyclin A2provided by MGI
Primary source: MGI:MGI:108069
See related: Ensembl:ENSMUSG00000027715 AllianceGenome:MGI:108069
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ccn1; Ccna; Cyca; Ccn-1; CycA2
Summary: Enables protein kinase binding activity. Acts upstream of or within positive regulation of DNA-templated transcription. Located in cytoplasm; female pronucleus; and male pronucleus. Part of cyclin A2-CDK1 complex and cyclin A2-CDK2 complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human CCNA2 (cyclin A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14 (RPKM 91.0), liver E14.5 (RPKM 83.6) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 17.67 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (36619014..36627187, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (36564865..36573038, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inducible expression of Oct-3/4 reveals synergy with Klf4 in targeting Cyclin A2 to enhance proliferation during early reprogramming.
Title: Inducible expression of Oct-3/4 reveals synergy with Klf4 in targeting Cyclin A2 to enhance proliferation during early reprogramming.
Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer.
Title: Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer.
Cyclin A2 is essential for mouse gonocyte maturation.
Title: Cyclin A2 is essential for mouse gonocyte maturation.
PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression.
Title: PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression.
The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway.
Title: The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway.
cyclin A2 functions in a noncanonical/non-cell cycle regulatory role to maintain adult pyramidal neuron ribostasis.
Title: CCNA2 Ablation in Aged Mice Results in Abnormal rRNA Granule Accumulation in Hippocampus.
We demonstrate that CCNA2-null progenitors suffer abnormal DNA repair, and implicate Cyclin A2 in double-strand break repair. Cyclin A2's DNA repair functions are conserved among cell lines, neural progenitors, and hippocampal neurons. We further demonstrate that neuronal CCNA2 ablation results in learning and memory deficits in aged mice.
Title: Cyclin A2 promotes DNA repair in the brain during both development and aging.
cyclin A2 mediates the fidelity ofmeiosis II by maintaining microtubule dynamics during the rapid formation of the meiosis II spindle.
Title: Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.
These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis.
Title: Cyclin A2 regulates erythrocyte morphology and numbers.
Meioc-deficient spermatocytes that have initiated synapsis mis-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program.
Title: Meioc maintains an extended meiotic prophase I in mice.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124728 (e-PCR)
- UniSTS:161550

PMC138456P2 (e-PCR)
- UniSTS:270870

PMC290270P3 (e-PCR)
- UniSTS:272418

PMC290270P4 (e-PCR)
- UniSTS:272419

Ccna2 (e-PCR), detects polymorphism
- UniSTS:238127

Bbs7 (e-PCR), detects polymorphism
- UniSTS:526919

D3Nds36 (e-PCR), detects polymorphism
- UniSTS:142412

PMC207566P2 (e-PCR)
- UniSTS:271955

PMC152357P1 (e-PCR)
- UniSTS:271221

Ccna2 (e-PCR), detects polymorphism
- UniSTS:526989

AA850100 (e-PCR)
- UniSTS:250257

PMC86923P2 (e-PCR)
- UniSTS:273557

PMC86923P3 (e-PCR)
- UniSTS:273558

PMC86923P4 (e-PCR)
- UniSTS:273559

PMC212738P1 (e-PCR)
- UniSTS:272027

Ccna2 (e-PCR), detects polymorphism
- UniSTS:506784

PMC317048P1 (e-PCR)
- UniSTS:273069

PMC165670P1 (e-PCR)
- UniSTS:271543

NoName (e-PCR)
- UniSTS:224444

Ccna2 (e-PCR), detects polymorphism
- UniSTS:141252

PMC309667P1 (e-PCR)
- UniSTS:272610

Ccna2 (e-PCR), detects polymorphism
- UniSTS:536560

RH134560 (e-PCR)
- UniSTS:217840

Ccna2 (e-PCR), detects polymorphism
- UniSTS:536561

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in G2/M transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in animal organ regeneration	IEA Inferred from Electronic Annotation more info
involved_in cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in cell cycle G1/S phase transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin-like growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leptin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to luteinizing hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitric oxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to platelet-derived growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	IEA Inferred from Electronic Annotation more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to glucagon	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cyclin A2-CDK1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cyclin A2-CDK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin A2-CDK2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of cyclin A2-CDK2 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in female pronucleus	IDA Inferred from Direct Assay more info	PubMed
located_in male pronucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cyclin-A2

Names: Cyclin A2 (Cyclin A); cyclin-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.