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    Eny2 ENY2 transcription and export complex 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 223527, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eny2provided by MGI
    Official Full Name
    ENY2 transcription and export complex 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1919286
    See related
    Ensembl:ENSMUSG00000022338 AllianceGenome:MGI:1919286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DC6; Ey2; 6720481I12; 1810057B09Rik
    Summary
    Predicted to enable chromatin binding activity and nuclear receptor coactivator activity. Predicted to be involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus; poly(A)+ mRNA export from nucleus; and regulation of DNA-templated transcription. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of SAGA complex and nucleus. Is expressed in midbrain ventricular layer; neural retinal epithelium; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human ENY2 (ENY2 transcription and export complex 2 subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 20.8), CNS E14 (RPKM 20.3) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Eny2 in Genome Data Viewer
    Location:
    15 B3.2; 15 16.91 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (44291488..44301652)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (44428082..44438256)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38570 Neighboring gene predicted gene, 24903 Neighboring gene predicted gene, 25093 Neighboring gene NudC domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E2440 Neighboring gene predicted gene, 22392 Neighboring gene polycystic kidney and hepatic disease 1-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E10853 Neighboring gene STARR-positive B cell enhancer ABC_E7366 Neighboring gene STARR-seq mESC enhancer starr_38573 Neighboring gene estrogen receptor-binding fragment-associated gene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in poly(A)+ mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of DUBm complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of DUBm complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of DUBm complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SAGA complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore nuclear basket ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription export complex 2 ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription export complex 2 ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription and mRNA export factor ENY2
    Names
    e(y)2 homolog
    e(y)2 protein
    enhancer of yellow 2 homolog
    enhancer of yellow 2 transcription factor homolog
    enhancer of yellow eye homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418909.1NP_001405838.1  transcription and mRNA export factor ENY2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127312
      UniProtKB/TrEMBL
      A0A2I3BRK6
      Related
      ENSMUSP00000154515.2, ENSMUST00000226827.2
    2. NM_175009.4NP_778174.1  transcription and mRNA export factor ENY2 isoform 1

      See identical proteins and their annotated locations for NP_778174.1

      Status: VALIDATED

      Source sequence(s)
      AC127312
      Consensus CDS
      CCDS27456.1
      UniProtKB/Swiss-Prot
      Q9JIX0
      Related
      ENSMUSP00000052905.4, ENSMUST00000060652.5
      Conserved Domains (1) summary
      pfam10163
      Location:1694
      EnY2; Transcription factor e(y)2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      44291488..44301652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)