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    Egr1 early growth response 1 [ Mus musculus (house mouse) ]

    Gene ID: 13653, updated on 9-Dec-2024

    Summary

    Official Symbol
    Egr1provided by MGI
    Official Full Name
    early growth response 1provided by MGI
    Primary source
    MGI:MGI:95295
    See related
    Ensembl:ENSMUSG00000038418 AllianceGenome:MGI:95295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    egr; TIS8; Zenk; Egr-1; NGFIA; Zfp-6; ETR103; Krox-1; Krox24; NGF1-A; NGFI-A; Zif268; Krox-24; A530045N19Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and enzyme binding activity. Involved in several processes, including cellular response to gamma radiation; regulation of gene expression; and regulation of hormone biosynthetic process. Acts upstream of or within several processes, including BMP signaling pathway; negative regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; jaw; and sensory organ. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 50.4), ovary adult (RPKM 42.9) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Egr1 in Genome Data Viewer
    Location:
    18 B1; 18 18.76 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34994260..34998009)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34861207..34864956)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44212 Neighboring gene KDM3B lysine (K)-specific demethylase 3B Neighboring gene STARR-seq mESC enhancer starr_44215 Neighboring gene receptor accessory protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E5650 Neighboring gene STARR-positive B cell enhancer ABC_E8958 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:35020809-35020992 Neighboring gene predicted gene, 54018 Neighboring gene eukaryotic translation termination factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E964

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded methylated DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded methylated DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables hemi-methylated DNA-binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hemi-methylated DNA-binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone acetyltransferase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to heparin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to heparin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to interleukin-8 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-8 ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to mycophenolic acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to mycophenolic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circadian temperature homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in estrous cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glomerular mesangial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glomerular mesangial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression via chromosomal CpG island demethylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of glomerular metanephric mesangial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glomerular metanephric mesangial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of hormone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of miRNA transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of post-translational protein modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of progesterone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to insulin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to ischemia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    early growth response protein 1
    Names
    Krox-24 nuclear protein
    nerve growth factor-induced protein A
    transcription factor Zif268
    zinc finger protein Krox-24

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007913.5NP_031939.1  early growth response protein 1

      See identical proteins and their annotated locations for NP_031939.1

      Status: VALIDATED

      Source sequence(s)
      AK037837, AK040925
      Consensus CDS
      CCDS29136.1
      UniProtKB/Swiss-Prot
      P08046, Q61777
      UniProtKB/TrEMBL
      Q3UM09, Q544D6, Q8CAT6
      Related
      ENSMUSP00000069616.6, ENSMUST00000064795.6
      Conserved Domains (7) summary
      COG5048
      Location:363421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:338360
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:336360
      zf-C2H2; Zinc finger, C2H2 type
      pfam05687
      Location:441478
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam11914
      Location:426520
      DUF3432; Domain of unknown function (DUF3432)
      pfam11928
      Location:132207
      DUF3446; Domain of unknown function (DUF3446)
      pfam13465
      Location:380405
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34994260..34998009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)